Hu L M, Jones R
Department of Pathology, Harvard Medical School, Children's Hospital, Boston, Massachusetts.
Am J Pathol. 1989 Feb;134(2):253-62.
Breathing 87% oxygen at normobaric pressure for 28 days injuries and remodels the wall of distal pulmonary veins (less than or equal to 150 mu). Occluded vessels are evident, as are vessel remnants in which wall integrity is lost (obliterated vessels). Significantly more veins have a muscular or partially muscular wall than normal (P less than or equal to 0.001 for veins in each size category less than or equal to 150 mu, chi-square test). In some veins new muscle develops between an external and internal lamina but in many it develops within the intima, beneath the endothelium and adluminal to a single lamina. Small veins (20-25 mu in ED) with a muscular or partially muscular wall are present only in the hyperoxic lung. Increase in the percent medial thickness (%MT) of veins indicates lumen narrowing: this is relatively greater in the smallest veins. Reduction in the cross-sectional area of venous segments that are immediately postcapillary, by lumen narrowing or occlusion, contributes to the restriction of the pulmonary vascular bed by hyperoxia.
在常压下呼吸87%的氧气28天会损伤并重塑远端肺静脉（直径小于或等于150微米）壁。可见闭塞的血管，以及壁完整性丧失的血管残余（闭塞血管）。与正常情况相比，具有肌肉性或部分肌肉性壁的静脉明显更多（对于直径小于或等于150微米的各尺寸类别静脉，P小于或等于0.001，卡方检验）。在一些静脉中，新的肌肉在内外膜之间形成，但在许多静脉中，它在内膜内、内皮下方且在单层内膜的管腔侧形成。具有肌肉性或部分肌肉性壁的小静脉（外径20 - 25微米）仅存在于高氧肺中。静脉中膜厚度百分比（%MT）的增加表明管腔变窄：这在最小的静脉中相对更明显。通过管腔变窄或闭塞，紧邻毛细血管后的静脉段横截面积减小，这导致高氧对肺血管床的限制。
