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动脉痉挛引起的内皮变化。

Endothelial changes induced by arterial spasm.

作者信息

Joris I, Majno G

出版信息

Am J Pathol. 1981 Mar;102(3):346-58.

PMID:7212018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1903722/
Abstract

Prolonged arterial constriction can cause damage to the artery itself. The purpose of this study was to define the intimal changes. Two muscular arteries of the rat were studied by electron microscopy 15 minutes to 7 days after L-norepinephrine had been dripped over the vessels. Endothelial damage was caused by the tight folding of the internal elastic lamina, which mechanically squeezed the cells. As the artery relaxed, the endothelium showed gaps, patches of thinned cytoplasm, and many adhesions between cells on opposite sides of intimal folds. The adhesions involved whole cells of cytoplasmic bridges stretched across the intimal "valleys." They were present up to one day; later they seemed to snap and disappear without causing further cellular damage. A survey of the literature shows that such adhesions can also develop in collapsed arteries postmortem. They explain the endothelial "bridges" previously described by others as a normal intimal structure.

摘要

动脉长期收缩会对动脉本身造成损害。本研究的目的是确定内膜变化。在大鼠的两条肌性动脉上滴注L-去甲肾上腺素15分钟至7天后，用电子显微镜进行研究。内皮损伤是由内弹性膜紧密折叠引起的，内弹性膜机械性挤压细胞。随着动脉舒张，内皮出现间隙、细胞质变薄区域以及内膜褶皱两侧细胞间的许多粘连。粘连涉及穿过内膜“谷底”的整个细胞质桥细胞。它们可持续存在一天；之后它们似乎断裂并消失，未造成进一步的细胞损伤。文献调查表明，这种粘连也可在死后塌陷的动脉中出现。它们解释了其他人之前描述为正常内膜结构的内皮“桥”。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/3ce068adca6d/amjpathol00222-0064-c.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/cfecfd4f5efe/amjpathol00222-0064-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/3ce068adca6d/amjpathol00222-0064-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/5f88ab1dfbb7/amjpathol00222-0056-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/3f84c4078999/amjpathol00222-0057-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/93a29dde7aab/amjpathol00222-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/12e6ffcb8d8c/amjpathol00222-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/d5f41798500e/amjpathol00222-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/bf88e84f59cb/amjpathol00222-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/04994a8a91f5/amjpathol00222-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/53d23970207f/amjpathol00222-0063-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/e2c279aa6747/amjpathol00222-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/cfecfd4f5efe/amjpathol00222-0064-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b914/1903722/3ce068adca6d/amjpathol00222-0064-c.jpg

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本文引用的文献

1
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Br Med J. 1952 Jan 12;1(4749):59-64. doi: 10.1136/bmj.1.4749.59.
2
Local spasm in cerebral arteries.脑动脉局部痉挛。
J Neurosurg. 1960 Jan;17:90-103. doi: 10.3171/jns.1960.17.1.0090.
3
THE PATHOGENESIS OF CEREBRAL INFARCTION FOLLOWING THE RUPTURE OF CEREBRAL BERRY ANEURYSMS.脑内浆果状动脉瘤破裂后脑梗死的发病机制
动脉动脉瘤动物模型的经验教训。
Aorta (Stamford). 2013 Oct 1;1(5):244-54. doi: 10.12945/j.aorta.2013.13-052. eCollection 2013 Oct.
4
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Am J Pathol. 1981 Dec;105(3):212-22.
5
Induction of acalculous cholecystitis and pneumonitis in dogs following inhalation of constituents of cigarette smoke condensate.吸入香烟烟雾冷凝物成分后犬非结石性胆囊炎和肺炎的诱发
Am J Pathol. 1982 Dec;109(3):253-8.
6
Hydrodynamic injury of the endothelium in acute aortic stenosis.急性主动脉瓣狭窄时内皮的流体动力学损伤。
Am J Pathol. 1982 Mar;106(3):394-408.
7
Adrenoreceptor blockade in angiotensin-induced hypertension: effect on rat coronary arteries and myocardium.肾上腺素能受体阻断在血管紧张素诱导的高血压中的作用：对大鼠冠状动脉和心肌的影响。
Am J Pathol. 1982 Jul;108(1):60-71.
8
Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit.乙酰甘油醚磷酸胆碱（AGEPC）诱导兔急性肺改变的动力学
Am J Pathol. 1985 Oct;121(1):55-68.
9
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Ann Surg. 1987 Dec;206(6):757-64. doi: 10.1097/00000658-198712000-00012.
10
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Acta Neurochir (Wien). 1987;89(1-2):71-6. doi: 10.1007/BF01406670.
Brain. 1964 Sep;87:491-510. doi: 10.1093/brain/87.3.491.
4
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Virchows Arch Pathol Anat Physiol Klin Med. 1963 Nov 8;337:97-141.
5
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Circ Res. 1962 Apr;10:668-75. doi: 10.1161/01.res.10.4.668.
6
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7
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