Kojima S, Matsuyama K, Kodera Y, Okada J
Division of Hematology/Oncology, Japanese Red Cross Nagoya First Hospital, Japan.
Br J Haematol. 1989 Jan;71(1):147-51. doi: 10.1111/j.1365-2141.1989.tb06289.x.
Lymphocyte subpopulations were measured in the blood of 21 children with severe aplastic anaemia (SAA). Five children with hepatitis-associated AA appeared to constitute a unique group. Compared with children with idiopathic AA, four of five children had a striking increase in percentage of activated suppressor T lymphocytes, which were defined by binding of both anti-Leu 2a and anti-HLA DR monoclonal antibodies (children with hepatitis-associated AA, 21.8 +/- 19.9% [mean +/- SD], children with idiopathic AA, 2.9 +/- 1.2%). However, there was no difference in the mean absolute number of the activated suppressor T lymphocytes between the two groups, because the mean number of lymphocytes was markedly less in children with hepatitis-associated AA (0.28 +/- 0.06 x 10(9)/l) than in those with idiopathic AA (1.64 +/- 0.74 x 10(9)/l). The mean helper: suppressor T lymphocyte ratio was significantly lower in children with hepatitis-associated AA (0.58 +/- 0.74) than in those with idiopathic AA (1.22 +/- 0.44). On the other hand, we did not find such a remarkable alteration of lymphocyte subpopulations in children with non-A non-B hepatitis who did not develop AA. These findings suggested that an imbalance of lymphocyte subpopulations and T lymphocyte activation may have pathogenetic relevance in some of the children with hepatitis-associated AA.
对21例重型再生障碍性贫血（SAA）患儿的血液进行了淋巴细胞亚群检测。5例肝炎相关性再生障碍性贫血患儿似乎构成一个独特的群体。与特发性再生障碍性贫血患儿相比，5例患儿中有4例活化抑制性T淋巴细胞百分比显著增加，活化抑制性T淋巴细胞通过抗Leu 2a和抗HLA DR单克隆抗体结合来定义（肝炎相关性再生障碍性贫血患儿为21.8±19.9%[均值±标准差]，特发性再生障碍性贫血患儿为2.9±1.2%）。然而，两组间活化抑制性T淋巴细胞的平均绝对数量并无差异，因为肝炎相关性再生障碍性贫血患儿的淋巴细胞平均数量（0.28±0.06×10⁹/L）明显低于特发性再生障碍性贫血患儿（1.64±0.74×10⁹/L）。肝炎相关性再生障碍性贫血患儿的辅助性T淋巴细胞与抑制性T淋巴细胞的平均比值（0.58±0.74）显著低于特发性再生障碍性贫血患儿（1.22±0.44）。另一方面，在未发生再生障碍性贫血的非甲非乙型肝炎患儿中，我们未发现淋巴细胞亚群有如此显著的改变。这些发现提示，淋巴细胞亚群失衡和T淋巴细胞活化可能与部分肝炎相关性再生障碍性贫血患儿的发病机制有关。
