在儿童慢性乙型肝炎病毒感染中，T淋巴细胞活化与病毒复制相关。
T lymphocyte activation is associated with viral replication in chronic hepatitis B virus infection of childhood.
作者信息
Vegnente A, Guida S, Lobo-Yeo A, Alviggi L, Daniels H, Toscano P, Nuzzo V, Mieli-Vergani G, Vergani D
机构信息
Dipartimento di Pediatria, II Facolta di Medicina, Naples, Italy.
出版信息
Clin Exp Immunol. 1991 May;84(2):190-4.
Activated circulating T lymphocytes expressing HLA-DR (mean +/- s.d. 11.0 +/- 5.2%) or interleukin-2 receptor (IL-2R) (2.1 +/- 1.7%) were significantly increased in 63 children with chronic hepatitis B virus (HBV) infection when compared with 33 age-matched healthy controls (3.0 +/- 1.3%, P less than 0.01, and 0.1 +/- 0.4%, P less than 0.01). HBeAg-positive patients had higher percentage of DR (11.9 +/- 5.1%) or IL-2R (2.4 +/- 1.7%) positive T lymphocytes than anti-HBe-positive children (7.4 +/- 3.6% and 1.1 +/- 1.5%, P less than 0.01 and P = 0.02 respectively). Similarly, HBV DNA-positive patients had higher percentage of DR (10.5 +/- 3.3) or IL-2R (3.2 +/- 1.7%) positive T cells than HBV DNA-negative children (6.6 +/- 2.8% and 1.2 +/- 1.5%, P less than 0.01 for both). There was a positive correlation between percentage of DR positive T lymphocytes and levels of HBV DNA. Sixty-two per cent of the DR-positive T lymphocytes were cytotoxic/suppressor and 35% helper/inducer. The relationship between viral replication and T lymphocyte activation is discussed.
与33名年龄匹配的健康对照儿童（3.0±1.3%，P<0.01；0.1±0.4%，P<0.01）相比，63例慢性乙型肝炎病毒（HBV）感染儿童中，表达HLA-DR（均值±标准差为11.0±5.2%）或白细胞介素-2受体（IL-2R）（2.1±1.7%）的活化循环T淋巴细胞显著增加。HBeAg阳性患者的DR阳性（11.9±5.1%）或IL-2R阳性（2.4±1.7%）T淋巴细胞百分比高于抗-HBe阳性儿童（分别为7.4±3.6%和1.1±1.5%，P<0.01和P=0.02）。同样，HBV DNA阳性患者的DR阳性（10.5±3.3）或IL-2R阳性（3.2±1.7%）T细胞百分比高于HBV DNA阴性儿童（分别为6.6±2.8%和1.2±1.5%，两者P均<0.01）。DR阳性T淋巴细胞百分比与HBV DNA水平之间呈正相关。62%的DR阳性T淋巴细胞为细胞毒性/抑制性，35%为辅助/诱导性。本文讨论了病毒复制与T淋巴细胞活化之间的关系。
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