Kumar Subramanian, Prahalathan Pichavaram, Raja Boobalan
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608002, Tamil Nadu, India.
Environ Toxicol Pharmacol. 2014 Sep;38(2):643-52. doi: 10.1016/j.etap.2014.07.011. Epub 2014 Jul 23.
The objective of the present study is to investigate the effects of vanillic acid on blood pressure, cardiac marker enzymes, left ventricular function and endothelial nitric oxide synthase (eNOS) expression in N(ω)-nitro-l-arginine methyl ester hydrochloride (l-NAME) induced hypertension in male albino Wistar rats. In hypertensive rats, mean arterial pressure (MAP), heart rate, cardiac marker enzymes and organ weight were increased. Impaired left ventricular function and decreased aortic eNOS expression was also observed in hypertensive rats. Moreover, treatment with vanillic acid exhibited beneficial effect on blood pressure, left ventricular function and cardiac marker enzymes. In addition, treatment with vanillic acid on hypertensive rats had upregulated eNOS expression and showed beneficial effects evidenced by histopathology and ultrastructural observations of aorta. In conclusion, vanillic acid has enough potential to normalize hypertension and left ventricular function in l-NAME induced hypertensive rats. With additional studies, vanillic acid might be used as a functional drug or as an adjuvant in the management of hypertension.
本研究的目的是探讨香草酸对N（ω）-硝基-L-精氨酸甲酯盐酸盐（L-NAME）诱导的雄性白化Wistar大鼠高血压模型的血压、心脏标志物酶、左心室功能及内皮型一氧化氮合酶（eNOS）表达的影响。在高血压大鼠中，平均动脉压（MAP）、心率、心脏标志物酶及器官重量均增加。高血压大鼠还出现左心室功能受损及主动脉eNOS表达降低。此外，香草酸治疗对血压、左心室功能及心脏标志物酶具有有益作用。另外，香草酸治疗高血压大鼠可上调eNOS表达，且通过主动脉的组织病理学和超微结构观察证明具有有益作用。总之，香草酸具有使L-NAME诱导的高血压大鼠血压和左心室功能恢复正常的足够潜力。通过进一步研究，香草酸可能用作功能性药物或高血压管理中的佐剂。
