Faculty of Pharmacy, Federal University of Goiás, Avenida Universitária s/n, 74605-220 Goiânia, GO, Brazil.
Unit of Exact and Technological Sciences, State University of Goiás, Caixa Postal 459, 75132-903 Anápolis, GO, Brazil.
Oxid Med Cell Longev. 2017;2017:2383157. doi: 10.1155/2017/2383157. Epub 2017 Dec 20.
Jabuticaba is an exotic fruit native to Brazil that has been arousing medicinal interest. Using chemical (HPLC-PDA, resonance mass spectra, and NMR), electroanalytical (differential pulse voltammetry, radical scavenging assay), and pharmacological ( and ) approaches, we have identified its bioactive compounds and hypotensive effects on hypertensive rats. The hydroalcoholic extract of jabuticaba (HEJ) presents a great quantity of phenolic compounds, and several molecules with hydroxyl groups present high efficiency as an antioxidant. The treatment with HEJ (100 and 300 mg/kg/day, for four weeks) presented hypotensive effects on L-NAME-induced hypertensive rats, possibly improving the nitric oxide bioavailability because of its high antioxidant potential. Furthermore, renal and cardiac hypertrophies were also attenuated after the HEJ treatment. Moreover, the vascular responses to contractile and dilating agonists were improved with the HEJ treatment, which is also able to induce nitric oxide production in endothelial cells.
嘉宝果是一种原产于巴西的外来水果，已引起医学兴趣。我们使用化学（HPLC-PDA、共振质谱和 NMR）、电化学（差分脉冲伏安法、自由基清除测定法）和药理学（和）方法，鉴定了其生物活性化合物及其对高血压大鼠的降压作用。嘉宝果的水醇提取物（HEJ）含有大量酚类化合物，并且一些含有羟基的分子作为抗氧化剂具有高效性。HEJ（100 和 300mg/kg/天，为期四周）治疗可降低 L-NAME 诱导的高血压大鼠的血压，可能由于其高抗氧化潜力而提高了一氧化氮的生物利用度。此外，肾和心脏肥大也在 HEJ 治疗后得到了缓解。此外，HEJ 治疗还改善了收缩和舒张激动剂引起的血管反应，并且还能够诱导内皮细胞产生一氧化氮。
