INSERM 930 & Université François Rabelais, F 37300 Tours, France.
Psychology Department, Swansea University, Singleton Park, Swansea SA2 8PP, UK.
Curr Opin Neurobiol. 2015 Feb;30:24-30. doi: 10.1016/j.conb.2014.08.013. Epub 2014 Sep 15.
Major depression is a psychiatric disorder with high prevalence. Both specialists in cognitive psychopathology and neurobiologists have proposed explanations of the process/systems that exhibit altered functioning during this disorder. Psychological processes that are dysfunctional in depressed patients include alterations in self-referential schemas, cognitive biases, ruminations and processing mode (over-general versus concrete). These cognitive processes are associated with altered function of specific brain systems, including prefrontal areas and cingulate cortex (both involved in self-referential processes and rumination), amygdala (cognitive bias), lateral habenula (cognitive bias) and hippocampus (cognitive bias and overgeneral processing). This review aims to present a coherent view integrating these two approaches in a unique model.
重度抑郁症是一种高发性精神障碍。认知心理病理学专家和神经生物学家都提出了在这种障碍中表现出功能改变的过程/系统的解释。在抑郁患者中功能失调的心理过程包括自我参照图式、认知偏差、沉思和加工模式（过度概括与具体）的改变。这些认知过程与特定大脑系统功能改变有关，包括前额叶区域和扣带皮层（都与自我参照过程和沉思有关）、杏仁核（认知偏差）、外侧缰核（认知偏差）和海马体（认知偏差和过度概括加工）。本综述旨在提出一个综合的观点，将这两种方法整合到一个独特的模型中。
