对罗马尼亚拟杆菌分离株的抗生素耐药水平及相应抗生素耐药基因进行分析。
Analysis of Romanian Bacteroides isolates for antibiotic resistance levels and the corresponding antibiotic resistance genes.
作者信息
Székely Edit, Eitel Zsuzsa, Molnár Szabolcs, Szász Izabella Éva, Bilca Doina, Sóki József
机构信息
Diagnostic Laboratory, Emergency County Clinical Hospital, Gh. Marinescu 50, Targu-Mures, 540139, Romania; Department of Microbiology, Faculty of Medicine, University of Medicine and Pharmacy of Targu Mures, Gh. Marinescu 38, Targu-Mures, 540139, Romania.
Institute of Clinical Microbiology, Faculty of Medicine, University of Szeged, Semmelweis 6 H-6725 Szeged, Hungary.
出版信息
Anaerobe. 2015 Feb;31:11-4. doi: 10.1016/j.anaerobe.2014.09.001. Epub 2014 Sep 10.
As part of an ESCMID Study Group on Anaerobic Infections (ESGAI) project, a study was conducted to measure the antibiotic susceptibilities and corresponding gene contents of 53 Bacteroides fragilis group strains isolated in Romania. The antibiotic resistance data was comparable with the data found for other East-European countries. Here, no resistant isolate was found for imipenem, metronidazole and tigecycline. An increasing role of the cepA, cfxA and cfiA genes was observed in their corresponding antibiotic resistances. Moreover, no isolate was found that harbored the cfiA gene with a possible activating IS element. Clindamycin resistance was low, similarly to that the rate for the ermF gene. However, we did find some isolates with nimB, ermB, msrSA, linA, satG, tetX, tetM and bexA genes. This study was the first to provide antibiotic resistance data for clinical Bacteroides strains from Romania.
作为欧洲临床微生物与感染病学会厌氧感染研究小组（ESGAI）项目的一部分，开展了一项研究，以测定在罗马尼亚分离出的53株脆弱拟杆菌群菌株的抗生素敏感性及相应的基因含量。抗生素耐药性数据与在其他东欧国家发现的数据具有可比性。在此研究中，未发现对亚胺培南、甲硝唑和替加环素耐药的分离株。观察到cepA、cfxA和cfiA基因在其相应抗生素耐药性中发挥着越来越重要的作用。此外，未发现携带可能具有激活作用的插入序列元件的cfiA基因的分离株。克林霉素耐药率较低，与ermF基因的耐药率相似。然而，我们确实发现了一些携带nimB、ermB、msrSA、linA、satG、tetX、tetM和bexA基因的分离株。这项研究首次提供了罗马尼亚临床拟杆菌菌株的抗生素耐药性数据。
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