通过结合经颅多普勒（TCD）速度和磁共振血管造影（MRA）直径来测量大脑中动脉血流：体外和体内验证
Middle cerebral artery blood flows by combining TCD velocities and MRA diameters: in vitro and in vivo validations.
作者信息
Yonan K A, Greene E R, Sharrar J M, Caprihan A, Qualls C, Roldan C A
机构信息
Department of Biology and Chemistry and Department of Computer of Mathematical Sciences, New Mexico Highlands University, Las Vegas, New Mexico.
Department of Biology and Chemistry and Department of Computer of Mathematical Sciences, New Mexico Highlands University, Las Vegas, New Mexico; Department of Internal Medicine and Cardiology Division, University of New Mexico School of Medicine, Albuquerque, New Mexico.
出版信息
Ultrasound Med Biol. 2014 Nov;40(11):2692-9. doi: 10.1016/j.ultrasmedbio.2014.05.022. Epub 2014 Sep 11.
Non-invasive transcranial Doppler (TCD) is widely used for blood velocity (BV, cm/sec) measurements in the human middle cerebral artery (MCA). MCABV measurements are accepted as linear with MCA blood flow (MCABF). Magnetic resonance angiography (MRA) provides measurements of MCA lumen diameters that can be combined with TCD MCABV to calculate MCABF (mL/min). We tested the precision and accuracy of this method against a flow phantom and in vivo proximal internal carotid artery blood flow (ICABF). In vitro precision (repeated measures) and accuracy (vs. time collection) gave correlations coefficients of 0.97 and 0.98, respectively (both p < 0.05). In vivo precision (repeated measures) and accuracy (vs. ICABF) gave correlation coefficients of 0.90 (left and right), 0.94 (left) and 0.93 (right) (all p < 0.05). Bilateral MCABF in 35 adults were similar (left, 168 ± 72 mL/min; right, 180 ± 69 mL/min; p > 0.05). Results suggest that blood velocity by TCD and lumen diameter by MRA can be combined to estimate absolute values of MCABF.
无创经颅多普勒（TCD）广泛用于测量人体大脑中动脉（MCA）的血流速度（BV，厘米/秒）。MCA血流速度测量结果被认为与MCA血流量（MCABF）呈线性关系。磁共振血管造影（MRA）可测量MCA管腔直径，该直径可与TCD测量的MCA血流速度相结合，以计算MCABF（毫升/分钟）。我们针对流动模型以及体内颈内动脉近端血流量（ICABF）测试了该方法的精密度和准确性。体外精密度（重复测量）和准确性（与时间采集对比）的相关系数分别为0.97和0.98（均p<0.05）。体内精密度（重复测量）和准确性（与ICABF对比）的相关系数分别为0.90（左右）、0.94（左侧）和0.93（右侧）（均p<0.05）。35名成年人的双侧MCABF相似（左侧，168±72毫升/分钟；右侧，180±69毫升/分钟；p>0.05）。结果表明，TCD测量的血流速度和MRA测量的管腔直径可结合起来估算MCABF的绝对值。
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