Department of Colorectal Surgery, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China; The First School of Clinical Medicine, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Department of Pharmaceutics, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210029, Jiangsu, China.
Cancer Lett. 2014 Dec 28;355(2):176-83. doi: 10.1016/j.canlet.2014.09.003. Epub 2014 Sep 10.
Cancer cells are characterized by altered glucose metabolism known as the Warburg effect in which aerobic glycolysis is increased. Glucose is converted to lactate even under sufficient oxygen tension. Interfering with this process may be a potential effective strategy to cause cancer cell death because these cells rely heavily on glucose metabolism for survival and proliferation. 2-Deoxy-D-glucose (2DG), a glucose analog, targets glucose metabolism to deplete cancer cells of energy. In addition, 2DG increases oxidative stress, inhibits N-linked glycosylation, and induces autophagy. It can efficiently slow cell growth and potently facilitate apoptosis in specific cancer cells. Although 2DG itself has limited therapeutic effect in many types of cancers, it may be combined with other therapeutic agents or radiotherapy to exhibit a synergistic anticancer effect. In this review, we describe the Warburg effect and discuss 2DG and its underlying mechanisms and potential application for cancer treatment.
癌细胞的特征是糖代谢发生改变，即众所周知的瓦博格效应，其中有氧糖酵解增加。即使在氧张力足够的情况下，葡萄糖也会转化为乳酸。干扰这一过程可能是一种潜在的有效策略，可以导致癌细胞死亡，因为这些细胞严重依赖葡萄糖代谢来生存和增殖。2-脱氧-D-葡萄糖（2DG）是一种葡萄糖类似物，靶向葡萄糖代谢以耗尽癌细胞的能量。此外，2DG 增加氧化应激，抑制 N-连接糖基化，并诱导自噬。它可以有效地减缓特定癌细胞的生长速度，并有效地促进细胞凋亡。虽然 2DG 本身在许多类型的癌症中治疗效果有限，但它可能与其他治疗剂或放射治疗联合使用，以表现出协同的抗癌作用。在这篇综述中，我们描述了瓦博格效应，并讨论了 2DG 及其潜在的机制和在癌症治疗中的应用。
