Nurjono Milawaty, Neelamekam Sasi, Lee Jimmy
Research Division, Institute of Mental Health, Singapore, Singapore.
Research Division, Institute of Mental Health, Singapore, Singapore; Department of General Psychiatry 1, Institute of Mental Health, Singapore, Singapore; Office of Clinical Sciences, Duke-NUS Graduate Medical School, Singapore, Singapore.
Psychoneuroendocrinology. 2014 Dec;50:149-54. doi: 10.1016/j.psyneuen.2014.08.017. Epub 2014 Sep 3.
Leptin plays an important role in the modulation of the dopaminergic system and has recently been implicated in schizophrenia. There have been conflicting reports on leptin levels in schizophrenia; as well as on the association between leptin levels and clinical symptoms. Therefore, this study aims to examine (i) leptin levels in schizophrenia relative to control, and (ii) the relationship between leptin and symptoms in schizophrenia. One hundred participants with schizophrenia and 89 healthy controls were recruited from the Institute of Mental Health in Singapore. Demographic information and medical histories were collected. Schizophrenia symptoms were assessed using the positive and negative syndrome scale (PANSS) and serum leptin was measured using a commercially available bioplex leptin assay. Linear regressions were performed to examine the relationship between serum leptin and the positive, negative, general psychopathology subscales and total PANSS scores. Contrary to previously published literature, we did not find any significant difference in leptin level between participants with schizophrenia compared to controls, which might be the result of recruited controls being of comparable body mass index. Serum leptin was found to be positively associated with positive symptoms, general psychopathology and total PANSS score. This study provides evidence to suggest a positive association between serum leptin level and symptomatology in schizophrenia. However, since conflicting results in this area of research exist, it is important to understand better the mechanism behind this relationship and to examine temporal fluctuations in leptin levels in relation with changes in clinical symptomatology.
瘦素在多巴胺能系统的调节中发挥着重要作用，最近被认为与精神分裂症有关。关于精神分裂症患者的瘦素水平以及瘦素水平与临床症状之间的关联，一直存在相互矛盾的报道。因此，本研究旨在探讨：（i）精神分裂症患者与对照组相比的瘦素水平；（ii）精神分裂症患者中瘦素与症状之间的关系。从新加坡心理健康研究所招募了100名精神分裂症患者和89名健康对照者。收集了人口统计学信息和病史。使用阳性和阴性症状量表（PANSS）评估精神分裂症症状，并使用市售的生物素瘦素检测法测量血清瘦素。进行线性回归以检验血清瘦素与阳性、阴性、一般精神病理学分量表及PANSS总分之间的关系。与先前发表的文献相反，我们发现精神分裂症患者与对照组相比，瘦素水平没有任何显著差异，这可能是由于招募的对照者体重指数相当所致。血清瘦素与阳性症状、一般精神病理学及PANSS总分呈正相关。本研究提供了证据表明血清瘦素水平与精神分裂症的症状学之间存在正相关。然而，由于该研究领域存在相互矛盾的结果，因此有必要更好地了解这种关系背后的机制，并研究瘦素水平与临床症状变化相关的时间波动情况。
