Qian Guangtao, Wang Zhicai, Zhao Jinyu, Li Dandan, Gao Wei, Wang Baohui, Sui Dayuan, Qu Xiangru, Chen Yanping
Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
Department of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
Steroids. 2014 Dec;92:1-6. doi: 10.1016/j.steroids.2014.08.021. Epub 2014 Sep 10.
β-d-Glucopyranoside,(3β,12β,20E)-12,25-dihydroxydammar-20(22)-en-3-yl (pseudo-ginsenoside Rh2) and its 20Z-isomer were synthesized from ginsenoside Rh2 under a mild condition, via a simple three-step called acetylation, elimination-addition and saponification. In addition, their activities were evaluated by eight different human tumor cells, compared with ginsenoside Rh2 group. Results indicated that the reaction in the side chain might greatly enhance the anti-proliferative activity of ginsenosides.
β -D-吡喃葡萄糖苷，(3β,12β,20E)-12,25-二羟基达玛-20(22)-烯-3-基（伪人参皂苷Rh2）及其20Z-异构体在温和条件下，通过乙酰化、消除-加成和皂化这一简单的三步反应从人参皂苷Rh2合成得到。此外，与人参皂苷Rh2组相比，通过八种不同的人类肿瘤细胞对它们的活性进行了评估。结果表明，侧链反应可能会大大增强人参皂苷的抗增殖活性。
