Kumar A
Department of Pediatrics and Human Development, Michigan State University, East Lansing 48824.
DICP. 1990 Mar;24(3):289-95. doi: 10.1177/106002809002400316.
Suppressor T lymphocytes possess histamine2 (H2) receptors and contribute significantly to the function of the immune system. Experimentally, cimetidine, an H2-receptor antagonist, has been shown to enhance a variety of immunologic functions both in vivo and in vitro because of its inhibitory effects on suppressor-cell function. Successful tumor immunotherapy, as well as some protection from infection, has been reported in experimental animals. Patients receiving cimetidine have been shown to exhibit enhanced cell-mediated immunity as evaluated by increased response to skin-test antigens, restoration of sensitivity following development of acquired tolerance, and increased responses of lymphocytes to mitogen stimulation. Preliminary reports also indicate that cimetidine may offer therapeutic benefits for patients with Varicella zoster and Herpes simplex infections, as well as those suffering from mucocutaneous candidiasis and common variable hypogammaglobulinemia. These immunoregulatory effects are dose-related but are not always consistent. Because of its inhibitory effect on suppressor function, cimetidine treatment may be deleterious in patients with organ transplant and autoimmune disorders. Cimetidine should be used as an immunomodulator on an experimental basis only.
抑制性T淋巴细胞拥有组胺2（H2）受体，对免疫系统的功能有重要作用。在实验中，H2受体拮抗剂西咪替丁已被证明可在体内和体外增强多种免疫功能，这是因为它对抑制性细胞功能具有抑制作用。在实验动物中已报道了成功的肿瘤免疫治疗以及一些抗感染保护作用。接受西咪替丁治疗的患者已显示出细胞介导免疫增强，这通过对皮肤试验抗原的反应增加、获得性耐受形成后敏感性的恢复以及淋巴细胞对有丝分裂原刺激的反应增加来评估。初步报告还表明，西咪替丁可能对水痘带状疱疹和单纯疱疹感染患者以及患有黏膜皮肤念珠菌病和常见可变低丙种球蛋白血症的患者具有治疗益处。这些免疫调节作用与剂量相关，但并不总是一致的。由于其对抑制功能的抑制作用，西咪替丁治疗对器官移植和自身免疫性疾病患者可能有害。西咪替丁仅应在实验基础上用作免疫调节剂。
