Elric Julien, Etienne-Manneville Sandrine
Institut Pasteur - CNRS URA 2582, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France; Université Pierre et Marie Curie, Cellule Pasteur UPMC, rue du Dr Roux, 75015 Paris, France.
Institut Pasteur - CNRS URA 2582, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France.
Exp Cell Res. 2014 Nov 1;328(2):240-8. doi: 10.1016/j.yexcr.2014.09.004. Epub 2014 Sep 8.
The centrosome position is tightly regulated during the cell cycle and during differentiated cellular functions. Because centrosome organizes the microtubule network to coordinate both intracellular organization and cell signaling, centrosome positioning is crucial to determine either the axis of cell division, the direction of cell migration or the polarized immune response of lymphocytes. Since alteration of centrosome positioning seems to promote cell transformation and tumor spreading, the molecular mechanisms controlling centrosome movement in response to extracellular and intracellular cues are under intense investigation. Evolutionary conserved pathways involving polarity proteins and cytoskeletal rearrangements are emerging as common regulators of centrosome positioning in a wide variety of cellular contexts.
中心体的位置在细胞周期和分化细胞功能过程中受到严格调控。由于中心体组织微管网络以协调细胞内组织和细胞信号传导，中心体定位对于确定细胞分裂轴、细胞迁移方向或淋巴细胞的极化免疫反应至关重要。由于中心体定位的改变似乎会促进细胞转化和肿瘤扩散，因此控制中心体响应细胞外和细胞内信号而移动的分子机制正在深入研究中。涉及极性蛋白和细胞骨架重排的进化保守途径正在成为多种细胞环境中中心体定位的常见调节因子。
