Lillie J W, Green M R
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
Nature. 1989 Mar 2;338(6210):39-44. doi: 10.1038/338039a0.
The adenovirus E1a protein stimulates transcription of a wide variety of viral and cellular genes. It is shown here that E1a has the two functions characteristic of a typical cellular activator: one direct E1a to the promoter, perhaps by interacting with a DNA-bound protein, and the other, an activating region, enables the bound activator to stimulate transcription.
腺病毒E1a蛋白可刺激多种病毒和细胞基因的转录。本文表明，E1a具有典型细胞激活剂的两种功能特性：一种功能将E1a引导至启动子，可能是通过与一种结合在DNA上的蛋白质相互作用来实现；另一种功能是激活区域，使结合的激活剂能够刺激转录。
