Martin K J, Lillie J W, Green M R
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
Nature. 1990 Jul 12;346(6280):147-52. doi: 10.1038/346147a0.
The adenovirus E1a protein (E1a), a potent transcription activator, contains a transcriptional activating region. Compared with previously described cellular and viral activators, E1a's activating region has unusual structural properties. It seems that E1a's activating region interacts with a cellular target not required for the function of transcriptional activators with 'acidic' activating regions. By contrast, the target of an acidic activating region is required both by acidic activators and by E1a. It is proposed that the cellular target of E1a's activating region is an 'adaptor' that allows E1a to interact with the basic transcriptional machinery.
腺病毒E1a蛋白（E1a）是一种强效转录激活因子，含有一个转录激活区域。与先前描述的细胞和病毒激活因子相比，E1a的激活区域具有不同寻常的结构特性。E1a的激活区域似乎与具有“酸性”激活区域的转录激活因子功能所不需要的细胞靶点相互作用。相比之下，酸性激活区域的靶点对于酸性激活因子和E1a都是必需的。有人提出，E1a激活区域的细胞靶点是一种“衔接蛋白”，它使E1a能够与基本转录机制相互作用。
