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皮肤癌的起源细胞。

Cells of origin in skin cancer.

机构信息

Division of General Dermatology, Medical University of Graz, Graz, Austria.

Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands.

出版信息

J Invest Dermatol. 2014 Oct;134(10):2491-2493. doi: 10.1038/jid.2014.233.

DOI:10.1038/jid.2014.233

PMID:25219650

Abstract

Adult skin stem cells do not protect their genome by asymmetric chromosome segregation; thus, they are prone to accumulating oncogenic mutations.

摘要

成人皮肤干细胞不会通过不对称的染色体分离来保护其基因组；因此，它们容易积累致癌突变。

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皮肤癌的起源细胞。

Cells of origin in skin cancer.

机构信息

Division of General Dermatology, Medical University of Graz, Graz, Austria.

Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands.

出版信息

J Invest Dermatol. 2014 Oct;134(10):2491-2493. doi: 10.1038/jid.2014.233.

DOI:10.1038/jid.2014.233

PMID:25219650

Abstract

Adult skin stem cells do not protect their genome by asymmetric chromosome segregation; thus, they are prone to accumulating oncogenic mutations.

摘要

成人皮肤干细胞不会通过不对称的染色体分离来保护其基因组；因此，它们容易积累致癌突变。

相似文献

1

Cells of origin in skin cancer.皮肤癌的起源细胞。

J Invest Dermatol. 2014 Oct;134(10):2491-2493. doi: 10.1038/jid.2014.233.

2

DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.DMBA/TPA 处理对于 Ptch(flox/flox)CD4Cre(+/-) 小鼠中 patched 缺失的表皮细胞形成 BCC 是必要的。

J Invest Dermatol. 2014 Oct;134(10):2620-2629. doi: 10.1038/jid.2014.157. Epub 2014 Mar 24.

3

Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis.转化生长因子-β共受体内皮糖蛋白在表皮角质形成细胞中的表达及其在小鼠皮肤多阶段致癌过程中的双重作用。

Oncogene. 2003 Sep 4;22(38):5976-85. doi: 10.1038/sj.onc.1206841.

4

Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis.桥粒芯糖蛋白2与 patched 1之间的相互作用加速化学诱导的皮肤肿瘤发生。

Oncotarget. 2015 Apr 20;6(11):8593-605. doi: 10.18632/oncotarget.3309.

5

E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice.E6 和 E7 来自 beta HPV38，与紫外线共同作用在小鼠中诱导光化性角化病样病变和鳞状细胞癌。

PLoS Pathog. 2011 Jul;7(7):e1002125. doi: 10.1371/journal.ppat.1002125. Epub 2011 Jul 14.

6

Modulation of patched-associated susceptibility to radiation induced tumorigenesis by genetic background.遗传背景对patched相关的辐射诱导肿瘤发生易感性的调节作用。

Cancer Res. 2004 Jun 1;64(11):3798-806. doi: 10.1158/0008-5472.CAN-03-3716.

7

Re-assessing K15 as an epidermal stem cell marker.重新评估 K15 作为表皮干细胞标志物。

Stem Cell Rev Rep. 2011 Nov;7(4):927-34. doi: 10.1007/s12015-011-9243-9.

8

Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis.与致癌作用起始相关的对终末分化具有抗性的小鼠皮肤细胞。

Nature. 1981 Sep 3;293(5827):72-4. doi: 10.1038/293072a0.

9

[Genetics of cancerogenesis. Experimental model in mice].

Pathol Biol (Paris). 1991 Feb;39(2):87-90.

10

Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFbetaRII.异常的细胞周期进程导致表达显性负性TGFβRII的转基因表皮早期致癌作用加速。

Oncogene. 2000 Jul 27;19(32):3623-31. doi: 10.1038/sj.onc.1203701.

引用本文的文献

1

Double-sided niche regulation in skin stem cell and cancer: mechanisms and clinical applications.皮肤干细胞与癌症中的双侧龛位调控：机制与临床应用

Mol Cancer. 2025 May 21;24(1):147. doi: 10.1186/s12943-025-02289-8.

2

Investigation of the RB1-SOX2 axis constitutes a tool for viral status determination and diagnosis in Merkel cell carcinoma.对RB1-SOX2轴的研究构成了一种用于默克尔细胞癌病毒状态确定和诊断的工具。

Virchows Arch. 2022 Jun;480(6):1239-1254. doi: 10.1007/s00428-022-03315-6. Epub 2022 Apr 12.

3

STING Signaling and Skin Cancers.

本文引用的文献

1

DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.DMBA/TPA 处理对于 Ptch(flox/flox)CD4Cre(+/-) 小鼠中 patched 缺失的表皮细胞形成 BCC 是必要的。

J Invest Dermatol. 2014 Oct;134(10):2620-2629. doi: 10.1038/jid.2014.157. Epub 2014 Mar 24.

2

Early B-cell differentiation in Merkel cell carcinomas: clues to cellular ancestry.默克尔细胞癌中的早期 B 细胞分化：细胞起源的线索。

Cancer Res. 2013 Aug 15;73(16):4982-7. doi: 10.1158/0008-5472.CAN-13-0616. Epub 2013 Apr 10.

3

Which are the cells of origin in merkel cell carcinoma?

相似文献

1

Cells of origin in skin cancer.皮肤癌的起源细胞。

J Invest Dermatol. 2014 Oct;134(10):2491-2493. doi: 10.1038/jid.2014.233.

2

DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.DMBA/TPA 处理对于 Ptch(flox/flox)CD4Cre(+/-) 小鼠中 patched 缺失的表皮细胞形成 BCC 是必要的。

J Invest Dermatol. 2014 Oct;134(10):2620-2629. doi: 10.1038/jid.2014.157. Epub 2014 Mar 24.

3

Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis.转化生长因子-β共受体内皮糖蛋白在表皮角质形成细胞中的表达及其在小鼠皮肤多阶段致癌过程中的双重作用。

Oncogene. 2003 Sep 4;22(38):5976-85. doi: 10.1038/sj.onc.1206841.

4

Crosstalk between Desmoglein 2 and Patched 1 accelerates chemical-induced skin tumorigenesis.桥粒芯糖蛋白2与 patched 1之间的相互作用加速化学诱导的皮肤肿瘤发生。

Oncotarget. 2015 Apr 20;6(11):8593-605. doi: 10.18632/oncotarget.3309.

5

E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice.E6 和 E7 来自 beta HPV38，与紫外线共同作用在小鼠中诱导光化性角化病样病变和鳞状细胞癌。

PLoS Pathog. 2011 Jul;7(7):e1002125. doi: 10.1371/journal.ppat.1002125. Epub 2011 Jul 14.

6

Modulation of patched-associated susceptibility to radiation induced tumorigenesis by genetic background.遗传背景对patched相关的辐射诱导肿瘤发生易感性的调节作用。

Cancer Res. 2004 Jun 1;64(11):3798-806. doi: 10.1158/0008-5472.CAN-03-3716.

7

Re-assessing K15 as an epidermal stem cell marker.重新评估 K15 作为表皮干细胞标志物。

Stem Cell Rev Rep. 2011 Nov;7(4):927-34. doi: 10.1007/s12015-011-9243-9.

8

Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis.与致癌作用起始相关的对终末分化具有抗性的小鼠皮肤细胞。

Nature. 1981 Sep 3;293(5827):72-4. doi: 10.1038/293072a0.

9

[Genetics of cancerogenesis. Experimental model in mice].

Pathol Biol (Paris). 1991 Feb;39(2):87-90.

10

Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFbetaRII.异常的细胞周期进程导致表达显性负性TGFβRII的转基因表皮早期致癌作用加速。

Oncogene. 2000 Jul 27;19(32):3623-31. doi: 10.1038/sj.onc.1203701.

引用本文的文献

1

Double-sided niche regulation in skin stem cell and cancer: mechanisms and clinical applications.皮肤干细胞与癌症中的双侧龛位调控：机制与临床应用

Mol Cancer. 2025 May 21;24(1):147. doi: 10.1186/s12943-025-02289-8.

2

Investigation of the RB1-SOX2 axis constitutes a tool for viral status determination and diagnosis in Merkel cell carcinoma.对RB1-SOX2轴的研究构成了一种用于默克尔细胞癌病毒状态确定和诊断的工具。

Virchows Arch. 2022 Jun;480(6):1239-1254. doi: 10.1007/s00428-022-03315-6. Epub 2022 Apr 12.

3

STING Signaling and Skin Cancers.

本文引用的文献

1

DMBA/TPA treatment is necessary for BCC formation from patched deficient epidermal cells in Ptch(flox/flox)CD4Cre(+/-) mice.DMBA/TPA 处理对于 Ptch(flox/flox)CD4Cre(+/-) 小鼠中 patched 缺失的表皮细胞形成 BCC 是必要的。

J Invest Dermatol. 2014 Oct;134(10):2620-2629. doi: 10.1038/jid.2014.157. Epub 2014 Mar 24.

2

Early B-cell differentiation in Merkel cell carcinomas: clues to cellular ancestry.默克尔细胞癌中的早期 B 细胞分化：细胞起源的线索。

Cancer Res. 2013 Aug 15;73(16):4982-7. doi: 10.1158/0008-5472.CAN-13-0616. Epub 2013 Apr 10.

3

Which are the cells of origin in merkel cell carcinoma?

干扰素基因刺激蛋白信号传导与皮肤癌

Cancers (Basel). 2021 Nov 9;13(22):5603. doi: 10.3390/cancers13225603.

4

Evidence of an epithelial origin of Merkel cell carcinoma.默克尔细胞癌上皮起源的证据。

Mod Pathol. 2022 Apr;35(4):446-448. doi: 10.1038/s41379-021-00964-x. Epub 2021 Nov 3.

5

Molecular profiling of basal cell carcinomas in young patients.年轻患者基底细胞癌的分子特征分析。

BMC Med Genomics. 2021 Jul 20;14(1):187. doi: 10.1186/s12920-021-01030-w.

6

Daily Lifestyle and Cutaneous Malignancies.日常生活方式与皮肤恶性肿瘤

Int J Mol Sci. 2021 May 14;22(10):5227. doi: 10.3390/ijms22105227.

7

The Paradoxical Behavior of microRNA-211 in Melanomas and Other Human Cancers.微小RNA-211在黑色素瘤及其他人类癌症中的矛盾行为

Front Oncol. 2021 Feb 8;10:628367. doi: 10.3389/fonc.2020.628367. eCollection 2020.

8

Merkel Cell Polyomavirus T Antigens Induce Merkel Cell-Like Differentiation in GLI1-Expressing Epithelial Cells.默克尔细胞多瘤病毒T抗原在表达GLI1的上皮细胞中诱导默克尔细胞样分化。

Cancers (Basel). 2020 Jul 21;12(7):1989. doi: 10.3390/cancers12071989.

9

Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs.皮肤癌研究进展：紫外线辐射、突变与反义寡核苷酸作为抗癌药物

Molecules. 2019 Apr 17;24(8):1516. doi: 10.3390/molecules24081516.

10

Recent Therapeutic Advances and Change in Treatment Paradigm of Patients with Merkel Cell Carcinoma.最近默克尔细胞癌患者的治疗进展和治疗模式的改变。

Oncologist. 2019 Oct;24(10):1375-1383. doi: 10.1634/theoncologist.2018-0718. Epub 2019 Apr 8.

默克尔细胞癌的起源细胞是什么？

J Skin Cancer. 2012;2012:680410. doi: 10.1155/2012/680410. Epub 2012 Dec 13.

4

Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource.利用全面的 Cre 特性资源支持条件性小鼠突变。

Nat Commun. 2012;3:1218. doi: 10.1038/ncomms2186.

5

MCV and Merkel cell carcinoma: a molecular success story.MCV 与 Merkel 细胞癌：分子水平的成功故事。

Curr Opin Virol. 2012 Aug;2(4):489-98. doi: 10.1016/j.coviro.2012.05.007. Epub 2012 Jun 17.

6

Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations.小鼠的基底细胞癌起源于毛囊干细胞和多个上皮祖细胞群体。

J Clin Invest. 2011 May;121(5):1768-81. doi: 10.1172/JCI46307. Epub 2011 Apr 25.

7

Cells of origin in cancer.癌症起源细胞。

Nature. 2011 Jan 20;469(7330):314-22. doi: 10.1038/nature09781.

8

Identification of epidermal progenitors for the Merkel cell lineage.鉴定默克尔细胞谱系的表皮祖细胞。

Development. 2010 Dec;137(23):3965-71. doi: 10.1242/dev.055970. Epub 2010 Nov 1.

9

Identification of the cell lineage at the origin of basal cell carcinoma.鉴定基底细胞癌起源处的细胞谱系。

Nat Cell Biol. 2010 Mar;12(3):299-305. doi: 10.1038/ncb2031. Epub 2010 Feb 14.

10

Epidermal progenitors give rise to Merkel cells during embryonic development and adult homeostasis.在胚胎发育和成年期稳态过程中，表皮祖细胞产生默克尔细胞。

J Cell Biol. 2009 Oct 5;187(1):91-100. doi: 10.1083/jcb.200907080. Epub 2009 Sep 28.

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皮肤癌的起源细胞。

Cells of origin in skin cancer.

机构信息

出版信息

文献检索

文件翻译

深度研究

皮肤癌的起源细胞。

Cells of origin in skin cancer.

机构信息

出版信息

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