Zhao J, Chen M, Quan C S, Fan S D
Key Laboratory of Biochemical Engineering State Ethnic Affairs Commission-Ministry of Education, Dalian Nationalities University, Dalian, China.
College of Life Science, Dalian Nationalities University, Dalian, China.
J Fish Dis. 2015 Sep;38(9):771-86. doi: 10.1111/jfd.12299. Epub 2014 Sep 15.
In many countries, infectious diseases are a considerable threat to aquaculture. The pathogenicity of micro-organisms that infect aquaculture systems is closely related to the release of virulence factors and the formation of biofilms, both of which are regulated by quorum sensing (QS). Thus, QS disruption is a potential strategy for preventing disease in aquaculture systems. QS inhibitors (QSIs) not only inhibit the expression of virulence-associated genes but also attenuate the virulence of aquaculture pathogens. In this review, we discuss QS systems in important aquaculture pathogens and focus on the relationship between QS mechanisms and bacterial virulence in aquaculture. We further elucidate QS disruption strategies for targeting aquaculture pathogens. Four main types of QSIs that target aquaculture pathogens are discussed based on their mechanisms of action.
在许多国家，传染病对水产养殖构成了相当大的威胁。感染水产养殖系统的微生物的致病性与毒力因子的释放和生物膜的形成密切相关，而这两者均受群体感应（QS）调控。因此，干扰群体感应是预防水产养殖系统疾病的一种潜在策略。群体感应抑制剂（QSIs）不仅能抑制毒力相关基因的表达，还能减弱水产养殖病原体的毒力。在本综述中，我们讨论了重要水产养殖病原体中的群体感应系统，并重点关注群体感应机制与水产养殖中细菌毒力之间的关系。我们进一步阐明了针对水产养殖病原体的群体感应干扰策略。基于其作用机制，讨论了四种主要类型的针对水产养殖病原体的群体感应抑制剂。
