Kasanah Noer, Ulfah Maria, Rowley David C
Department of Fisheries, Faculty of Agriculture, Universitas Gadjah Mada Indonesia
Integrated Lab. Agrocomplex, Faculty of Agriculture, Universitas Gadjah Mada Indonesia.
RSC Adv. 2022 Dec 1;12(53):34531-34547. doi: 10.1039/d2ra05076e. eCollection 2022 Nov 29.
Vibriosis causes serious problems and economic loss in aquaculture and human health. Investigating natural products as antivibrio agents has gained more attention to combat vibriosis. The present review highlights the chemical diversity of antivibrio isolated from bacteria, fungi, plants, and marine organisms. Based on the study covering the literature from 1985-2021, the chemical diversity ranges from alkaloids, terpenoids, polyketides, sterols, and peptides. The mechanisms of action are included inhibiting growth, interfering with biofilm formation, and disrupting of quorum sensing. Relevant summaries focusing on the source organisms and the associated bioactivity of different chemical classes are also provided. Further research on studies, toxicity, and clinical is required for the application in aquaculture and human health.
弧菌病在水产养殖和人类健康方面会引发严重问题并造成经济损失。研究天然产物作为抗弧菌剂以对抗弧菌病已受到更多关注。本综述重点介绍了从细菌、真菌、植物和海洋生物中分离出的抗弧菌物质的化学多样性。基于对1985年至2021年文献的研究，化学多样性涵盖生物碱、萜类化合物、聚酮化合物、甾醇和肽类。其作用机制包括抑制生长、干扰生物膜形成以及破坏群体感应。还提供了关于来源生物以及不同化学类别相关生物活性的相关总结。在水产养殖和人类健康应用方面，还需要对研究、毒性和临床进行进一步研究。
