Simeoni Umberto, Yzydorczyk Catherine, Siddeek Benazir, Benahmed Mohamed
Division of Pediatrics & DOHaD Laboratory, CHUV & University of Lausanne Switzerland.
Division of Pediatrics & DOHaD Laboratory, CHUV & University of Lausanne Switzerland.
Early Hum Dev. 2014 Sep;90 Suppl 2:S23-4. doi: 10.1016/S0378-3782(14)50007-2.
Epigenetic changes have long-lasting effects on gene expression and are related to, and often induced by, the environment in which early development takes place. In particular, the period of development that extends from pre-conception to early infancy is the period of life during which epigenetic DNA imprinting activity is the most active. Epigenetic changes have been associated with modification of the risk for developing a wide range of adulthood, non-communicable diseases (including cardiovascular diseases, metabolic diseases, diseases of the reproductive system, etc.). This paper reviews the molecular basis of epigenetics, and addresses the issues related to the process of developmental programming of the various areas of human health.
表观遗传变化对基因表达具有长期影响，并且与早期发育所处的环境相关，且常常由该环境诱导产生。特别是，从受孕前到婴儿早期的发育阶段是表观遗传DNA印记活动最为活跃的生命时期。表观遗传变化与多种成年期非传染性疾病（包括心血管疾病、代谢性疾病、生殖系统疾病等）发生风险的改变有关。本文综述了表观遗传学的分子基础，并探讨了与人类健康各个领域发育编程过程相关的问题。
