Department of Ophthalmology, Bozok University Faculty of Medicine, Yozgat, Turkey.
Cornea. 2014 Nov;33(11):1238-9. doi: 10.1097/ICO.0000000000000255.
To report a case of marginal keratitis that developed after intravitreal ranibizumab injection.
A 56-year-old man with diffuse diabetic macular edema received intravitreal injection of ranibizumab into his right eye.
One day after injection, the patient presented with pain, redness, tearing, and discomfort in his right eye. Anterior segment examination of the right eye revealed subconjunctival hemorrhage, 3 corneal subepithelial peripheral infiltrates separated from the limbus by a clear zone, and mild anterior chamber reaction. Examination of the eyelids was remarkable for mild blepharitis. Fungal and bacterial cultures were negative. The condition resolved with topical corticosteroids and antibiotics.
Intravitreal ranibizumab injection may trigger hypersensitivity reaction in the form of marginal keratitis in patients with mild blepharitis.
报告一例玻璃体内注射雷珠单抗后发生的周边性角膜炎。
一名 56 岁男性患者因弥漫性糖尿病性黄斑水肿接受右眼玻璃体内雷珠单抗注射。
注射后 1 天，患者右眼出现疼痛、发红、流泪和不适。右眼眼前节检查显示结膜下出血，3 个角膜上皮下周边浸润灶与角膜缘之间有一清晰带分开，前房反应轻微。眼睑检查可见轻度睑缘炎。真菌和细菌培养均为阴性。局部应用皮质类固醇和抗生素后病情缓解。
对于患有轻度睑缘炎的患者，玻璃体内注射雷珠单抗可能会引发以周边性角膜炎为表现的过敏反应。
