Kim Hee Jun, Ahn Hyeon Yeong, Kwak Jung Hyun, Shin Dong Yeob, Kwon Young-In, Oh Chen-Gum, Lee Jong Ho
Interdisciplinary Course of Science for Aging, Graduate School, Yonsei University, 134 Shinchon-Dong, Seodaemun-Gu, Seoul, Republic of Korea.
Food Funct. 2014 Oct;5(10):2662-9. doi: 10.1039/c4fo00469h. Epub 2014 Sep 15.
We aimed to evaluate the effect of chitosan oligosaccharide (GO2KA1) supplementation on glucose control in subjects with prediabetes. This study was a randomized, double-blind, placebo-controlled clinical trial. Subjects with prediabetes were randomly assigned to the GO2KA1 intervention group or the placebo group for 12 weeks. We assessed the serum levels of glucose, insulin, and C-peptide by a 2 hour value in the 75 g oral glucose tolerance test (OGTT), HbA1c, pro-inflammatory cytokines, and plasma adiponectin at baseline and after the 12 week intervention. The treatment group showed a significant decrease in the serum glucose level at 30 min (p = 0.013) and at 60 min (p = 0.028). The change of the serum glucose level at 60 min was significant in the treatment group compared with the placebo group (p = 0.030). Also, the plasma level of HbA1c (p = 0.023) and the pro-inflammatory cytokines (IL-6 and TNF-α) were reduced and plasma adiponectin was increased in the GO2KA1 intervention group after the 12 week treatment. However, the placebo group did not show any significant changes in these biomarkers. In subjects with prediabetes, 12 week supplement with GO2KA1 may help control postprandial glucose compared with control.
我们旨在评估补充壳寡糖（GO2KA1）对糖尿病前期患者血糖控制的影响。本研究为一项随机、双盲、安慰剂对照的临床试验。将糖尿病前期患者随机分为GO2KA1干预组或安慰剂组，为期12周。我们在基线和12周干预后，通过75克口服葡萄糖耐量试验（OGTT）中的2小时值、糖化血红蛋白（HbA1c）、促炎细胞因子和血浆脂联素来评估血清葡萄糖、胰岛素和C肽水平。治疗组在30分钟时血清葡萄糖水平显著降低（p = 0.013），在60分钟时也显著降低（p = 0.028）。与安慰剂组相比，治疗组在60分钟时血清葡萄糖水平的变化具有显著性（p = 0.030）。此外，在12周治疗后，GO2KA1干预组的糖化血红蛋白血浆水平（p = 0.023）和促炎细胞因子（白细胞介素-6和肿瘤坏死因子-α）降低，血浆脂联素升高。然而，安慰剂组在这些生物标志物方面未显示任何显著变化。在糖尿病前期患者中，与对照组相比，补充12周的GO2KA1可能有助于控制餐后血糖。
