Department of Biomedical Engineering, Texas A&M University, MS 3120, 5045 Emerging Technologies Building, College Station, TX 77843, USA.
Texas Institute for Preclinical Studies, Texas A&M University, MS 4478, College Station, TX 77845, USA.
J Mech Behav Biomed Mater. 2014 Dec;40:102-114. doi: 10.1016/j.jmbbm.2014.07.037. Epub 2014 Aug 11.
Predominantly closed-cell low density shape memory polymer (SMP) foam was recently reported to be an effective aneurysm filling device in a porcine model (Rodriguez et al., Journal of Biomedical Materials Research Part A 2013: (http://dx.doi.org/10.1002/jbm.a.34782)). Because healing involves blood clotting and cell migration throughout the foam volume, a more open-cell structure may further enhance the healing response. This research sought to develop a non-destructive reticulation process for this SMP foam to disrupt the membranes between pore cells. Non-destructive mechanical reticulation was achieved using a gravity-driven floating nitinol pin array coupled with vibratory agitation of the foam and supplemental chemical etching. Reticulation resulted in a reduced elastic modulus and increased permeability, but did not impede the shape memory behavior. Reticulated foams were capable of achieving rapid vascular occlusion in an in vivo porcine model.
最近有研究报道称，主要为闭孔结构的低密度形状记忆聚合物（SMP）泡沫在猪模型中是一种有效的动脉瘤填充装置（Rodriguez 等人，《生物医学材料研究杂志 A 部分》2013 年：（http://dx.doi.org/10.1002/jbm.a.34782））。由于愈合过程涉及到整个泡沫体积中的血液凝结和细胞迁移，因此更开孔结构可能会进一步增强愈合反应。本研究旨在为这种 SMP 泡沫开发一种非破坏性的交联工艺，以破坏孔细胞之间的细胞膜。通过使用重力驱动的漂浮镍钛诺销阵列结合泡沫的振动搅拌和补充化学蚀刻，实现了非破坏性的机械交联。交联导致弹性模量降低和渗透性增加，但不影响形状记忆性能。交联泡沫能够在体内猪模型中实现快速血管闭塞。
