控制低密度形状记忆聚合物泡沫在水中的驱动速率
Controlling the Actuation Rate of Low-Density Shape-Memory Polymer Foams in Water.
作者信息
Singhal Pooja, Boyle Anthony, Brooks Marilyn L, Infanger Stephen, Letts Steve, Small Ward, Maitland Duncan J, Wilson Thomas S
机构信息
Department of Biomedical Engineering, 5045 Emerging Technologies Building, 3120 TAMU, College Station, TX-77843, USA.
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore CA-94550, USA.
出版信息
Macromol Chem Phys. 2013 Jun 13;214(11):1204-1214. doi: 10.1002/macp.201200342.
Abstract
SMPs have been shown to actuate below their dry glass transition temperatures in the presence of moisture due to plasticization. This behavior has been proposed as a self-actuating mechanism of SMPs in water/physiological media. However, control over the SMP actuation rate, a critical factor for in vivo transcatheter device delivery applications, has not been previously reported. Here, a series of polyurethane SMPs with systematically varied hydrophobicity is described that permits control of the time for their complete shape recovery in water from under 2 min to more than 24 h. This control over the SMP actuation rate can potentially provide significant improvement in their delivery under conditions, which may expose them to high-moisture environments prior to actuation.
摘要
由于增塑作用，形状记忆聚合物（SMPs）已被证明在有水分存在的情况下，会在其干态玻璃化转变温度以下发生驱动。这种行为被认为是SMPs在水/生理介质中的一种自驱动机制。然而，对于SMP驱动速率的控制，这一用于体内经导管装置递送应用的关键因素，此前尚未见报道。在此，描述了一系列具有系统变化疏水性的聚氨酯SMPs，其能够将它们在水中完全恢复形状的时间从不到2分钟控制到超过24小时。对SMP驱动速率的这种控制有可能在其递送条件下带来显著改善，在这些条件下，它们在驱动前可能会暴露于高湿度环境中。
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