Department of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, and BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.
ACS Appl Bio Mater. 2021 Sep 20;4(9):6769-6779. doi: 10.1021/acsabm.1c00516. Epub 2021 Aug 11.
Uncontrolled hemorrhage is the leading cause of preventable death on the battlefield and results in ∼1.5 million deaths each year. The primary current treatment options are gauze and/or tourniquets, which are ineffective for up to 80% of wounds. Additionally, most hemostatic materials must be removed from the patient within <12 h, which limits their applicability in remote scenarios and can cause additional bleeding upon removal. Here, degradable shape memory polymer (SMP) foams were synthesized to overcome these limitations. SMP foams were modified with oxidatively labile ether groups and hydrolytically labile ester groups to degrade after implantation. Foam physical, thermal, and shape memory properties were assessed along with cytocompatibility and blood interactions. Degradation profiles were obtained in vitro in oxidative and hydrolytic media (3% HO (oxidation) and 0.1 M NaOH (hydrolysis) at 37 °C). The resulting foams had tunable, clinically relevant degradation rates, with complete mass loss within 30-60 days. These SMP foams have potential to provide an easy-to-use, shape-filling hemostatic dressing that can be left in place during traumatic wound healing with future potential use in regenerative medicine applications.
失控性出血是战场上可预防死亡的主要原因，每年导致约 150 万人死亡。目前主要的治疗选择是纱布和/或止血带，但对多达 80%的伤口无效。此外，大多数止血材料必须在<12 h 内从患者体内取出，这限制了它们在偏远环境中的适用性，并可能在取出时导致额外出血。在这里，可降解形状记忆聚合物（SMP）泡沫被合成以克服这些限制。SMP 泡沫用氧化不稳定的醚基团和水解不稳定的酯基团进行改性，以在植入后降解。评估了泡沫的物理、热和形状记忆性能以及细胞相容性和血液相互作用。在体外的氧化和水解介质（3%HO（氧化）和 0.1 M NaOH（水解），37°C）中获得了降解曲线。得到的泡沫具有可调节的、临床相关的降解速率，在 30-60 天内完全失重。这些 SMP 泡沫有可能提供一种易于使用的、形状填充的止血敷料，可在创伤性伤口愈合期间留在原处，未来可能用于再生医学应用。
