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β-内啡肽参与兔下丘脑“饥饿中枢”神经元活动的组织过程

[Participation of beta-endorphins in organizing neuronal activity of the rabbit hypothalamic "hunger centers"].

作者信息

Figurov A I, Mishcheriakov A F

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1989 Jan;75(1):13-8.

PMID:2522399
Abstract

Microiontophoretic application of beta-endorphin activated neuronal activity (48%) rather than inhibited it (38%) or had no effect whatsoever (14%) in the later hypothalamus of satiated rabbits. Naloxone inhibited the neuronal activity in 75% of the cases as well as activated it (25%), no areactive neurons having been found. The variations of latency of the interspike intervals due to the effect of beta-endorphin depended on the background activity of the neurons. The beta-endorphin--sensitive neurons seem to play a part both in neuronal mechanisms of feeding motivation and in those of satiation.

摘要

在饱腹家兔下丘脑后部,微量离子导入β-内啡肽激活神经元活动的情况占48%,抑制神经元活动的情况占38%,无任何影响的情况占14%。纳洛酮在75%的情况下抑制神经元活动,同时在25%的情况下激活神经元活动,未发现无反应神经元。β-内啡肽作用引起的峰电位间期潜伏期变化取决于神经元的背景活动。β-内啡肽敏感神经元似乎在摄食动机的神经元机制和饱腹感的神经元机制中都起作用。

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