Lutz G, Niedecken H, Bauer R, Kreysel H W
Department of Dermatology, Rheinische Friedrich-Wilhelms-Universität, Bonn, FRG.
Dermatologica. 1989;178(2):64-6. doi: 10.1159/000248393.
Since previous studies have shown that circulating T cytotoxic/suppressor cells and natural killer cells are reduced in alopecia areata (AA), we attempted to find further imbalances in mononuclear cells by double labeling with these and additional monoclonal antibodies. In all, the blood of 35 patients and 44 controls was examined using the combinations anti-Leu 3a/8, Leu 2a/8, Leu 2a/15, Leu 7/15 and Leu 7/11a. We found a highly significant reduction of the subpopulation Leu 2a+8+ (p less than 0.008). The results show that patients with AA have additional abnormalities of the circulating mononuclear cells, whereby the reduced Leu 2a+8+ subpopulation represents a new additional marker.
由于先前的研究表明，斑秃（AA）患者循环中的细胞毒性/抑制性T细胞和自然杀伤细胞减少，我们试图通过用这些抗体和其他单克隆抗体进行双重标记，来进一步发现单核细胞中的失衡情况。总共使用抗Leu 3a/8、Leu 2a/8、Leu 2a/15、Leu 7/15和Leu 7/11a组合检测了35例患者和44例对照者的血液。我们发现Leu 2a+8+亚群显著减少（p小于0.008）。结果表明，斑秃患者的循环单核细胞存在其他异常，其中Leu 2a+8+亚群减少代表一种新的额外标志物。
