不同临床阶段斑秃患者的外周血T细胞亚群

Peripheral T-cell subsets in patients with alopecia areata in different clinical phases.

作者信息

Valsecchi R, Bontempelli M, Vicari O, Frigeni A, Foiadelli L, Cainelli T

出版信息

Dermatologica. 1985;171(3):170-4. doi: 10.1159/000249413.

Abstract

An analysis of T-cell subpopulations was carried out in the peripheral blood of 21 subjects with alopecia areata (AA) of the scalp in various phases of its evolution and in 18 healthy control subjects by means of different monoclonal antibodies of OKT series (T3, T4, T8, T11). Patients with AA in active phase showed a significant reduction of OKT 8+ cells (p less than 0.002) and a significant increase of OKT 4+ cells (p less than 0.002) versus controls. On the contrary, patients with regrowing hair showed a significant increase of circulating OKT 8+ cells compared with controls (p less than 0.002). No abnormality in the distribution of T-cell subsets in patients with AA in stable phase has been observed.

摘要

采用OKT系列不同单克隆抗体（T3、T4、T8、T11），对21例处于头皮斑秃（AA）演变各阶段的患者外周血及18名健康对照者的外周血进行T细胞亚群分析。与对照组相比，处于活动期的AA患者OKT 8+细胞显著减少（p<0.002），OKT 4+细胞显著增加（p<0.002）。相反，毛发再生的患者与对照组相比，循环OKT 8+细胞显著增加（p<0.002）。未观察到处于稳定期的AA患者T细胞亚群分布有异常。