Ledesma G N, York K K
Arch Dermatol Res. 1982;274(1-2):1-8. doi: 10.1007/BF00510352.
There is considerable evidence to suggest that autoimmunity plays a role in the pathogenesis of alopecia areata. Since it is known that T cells regulate the immune system, a study was undertaken to measure T helper (OKT-4) and T suppressor (OKT-8) cells in the peripheral blood of patients with alopecia areata (both active and stable) and in controls. Total T cells, B cells, immunoglobulins, and autoantibodies were also measured. There was a highly significant decrease in the T-suppressor cell population of patients with alopecia areata (P less than 0.001). Two of ten patients had microsomal antibodies and three of ten had elevated IgE levels. Other parameters were not significantly different. The decrease in suppressor cells suggest an impairment of the prime negative regulator of the immune system, with loss of tolerance and resultant autoimmunity.
有大量证据表明自身免疫在斑秃的发病机制中起作用。由于已知T细胞调节免疫系统，因此开展了一项研究，以测量斑秃患者（包括活动期和稳定期）及对照组外周血中的辅助性T细胞（OKT - 4）和抑制性T细胞（OKT - 8）。还测量了总T细胞、B细胞、免疫球蛋白和自身抗体。斑秃患者的抑制性T细胞群体显著减少（P小于0.001）。十名患者中有两名有微粒体抗体，十名中有三名IgE水平升高。其他参数无显著差异。抑制性细胞的减少表明免疫系统的主要负调节因子受损，导致耐受性丧失和自身免疫。
