Koh Young Wha, Jung Se Jin, Yoon Dok Hyun, Suh Cheolwon, Cha Hee Jeong, Go Heounjeong, Kim Ji Eun, Kim Chul-Woo, Huh Jooryung
Department of Pathology, Ajou University School of Medicine, Suwon, South Korea.
Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea.
Hematol Oncol. 2015 Sep;33(3):133-40. doi: 10.1002/hon.2155. Epub 2014 Sep 16.
Recent studies suggest that absolute lymphocyte count, absolute monocyte count and their ratio [lymphocyte/monocyte ratio (LMR)] at diagnosis may predict survival in classical Hodgkin lymphoma (cHL). Here, we investigated the prognostic significance of LMR in cHL patients in relation to age of patients. Subjects included 351 cHL patients (age range from 4 to 84 years, median age 34 years, sex ratio 1.58) who had been followed-up for a median period of 59 months (range, 0.1-245 months). The estimated 5-year overall survival (OS) rate was 86.8%. Subgroup analysis was performed according to patients' age; non-elderly group (<60 years of age) versus elderly group (≥60 years of age). There was no significant difference in the level of absolute lymphocyte count, absolute monocyte count or LMR between the age groups. Using receiver operating characteristic curve analysis, the optimal cut-off value of LMR for the entire cohort was determined at 2.8, whereas the optimal cut-off for the elderly group was 2.2. In the non-elderly group (<60 years old), patients with LMR <2.8 had significantly lower OS or lymphoma-specific survival compared with those with LMR ≥2.8 (p < 0.001, both). In contrast, neither the LMR value of 2.8 or 2.2 predicted survival in the elderly group. In multivariate analysis, LMR remained a significant prognostic factor for OS (p = 0.049). The results of our analysis suggest that low LMR is associated with poor OS in patients of <60 years old.
近期研究表明，经典型霍奇金淋巴瘤（cHL）诊断时的绝对淋巴细胞计数、绝对单核细胞计数及其比值[淋巴细胞/单核细胞比值（LMR）]可能预测生存情况。在此，我们研究了cHL患者中LMR与患者年龄相关的预后意义。研究对象包括351例cHL患者（年龄范围4至84岁，中位年龄34岁，性别比1.58），中位随访时间为59个月（范围0.1至245个月）。估计的5年总生存率（OS）为86.8%。根据患者年龄进行亚组分析；非老年组（<60岁）与老年组（≥60岁）。年龄组之间的绝对淋巴细胞计数、绝对单核细胞计数或LMR水平无显著差异。采用受试者工作特征曲线分析，确定整个队列LMR的最佳截断值为2.8，而老年组的最佳截断值为2.2。在非老年组（<60岁）中，LMR<2.8的患者与LMR≥2.8的患者相比，OS或淋巴瘤特异性生存率显著更低（均为p<0.001）。相反，2.8或2.2的LMR值均不能预测老年组的生存情况。多因素分析中，LMR仍然是OS的显著预后因素（p = 0.049）。我们的分析结果表明，低LMR与<60岁患者的不良OS相关。
