Anderud Jonas, Jimbo Ryo, Abrahamsson Peter, Isaksson Sten G, Adolfsson Erik, Malmström Johan, Kozai Yusuke, Hallmer Fredrik, Wennerberg Ann
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden; Maxillofacial Unit Halmstad, Region Halland, Halmstad, Sweden.
Department of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Nov;118(5):532-8. doi: 10.1016/j.oooo.2014.06.011. Epub 2014 Jul 3.
The purpose of this study was to evaluate 3-dimensionally whether vertical bone augmentation can be achieved using a hollow hydroxyapatite space-maintaining device in a rabbit calvarial model. Furthermore, different inner surface topographies, different permeabilities, and different porosities of the ceramic were tested to determine the optimal conditions for bone regeneration.
A total of 48 hollow domes made of hydroxyapatite in 4 different designs were placed subperiosteally on rabbit skull bone. The rabbits were humanely killed after 12 weeks, and the results were analyzed 3-dimensionally using micro-computed tomography.
The results suggest a larger production of bone volume when using an occlusive, dense hydroxyapatite space-maintaining device with a rough inner surface.
Hydroxyapatite space-maintaining devices permit new bone formation and osteoconduction within the dome.
本研究旨在通过兔颅骨模型，三维评估使用中空羟基磷灰石间隙维持装置能否实现垂直骨增量。此外，还测试了陶瓷不同的内表面形貌、不同的渗透性和不同的孔隙率，以确定骨再生的最佳条件。
将4种不同设计的共48个由羟基磷灰石制成的中空圆顶置于兔颅骨骨膜下。12周后对兔子实施安乐死，然后使用微型计算机断层扫描进行三维结果分析。
结果表明，使用具有粗糙内表面的封闭、致密羟基磷灰石间隙维持装置时，骨体积生成量更大。
羟基磷灰石间隙维持装置可使圆顶内形成新骨并具有骨传导性。
