Kim Joong-Min, Kim Joong-Hyun, Lee Byeong-Han, Choi Seok Hwa
e-Well Dental Hospital, Seoul, Republic of Korea.
Department of Dentistry, Graduate School of Medicine, Korea University, Seoul, Republic of Korea.
In Vivo. 2018 Sep-Oct;32(5):1111-1117. doi: 10.21873/invivo.11353.
BACKGROUND/AIM: Lost alveolar bone is commonly restored by distraction osteogenesis or bone blocks for substantial vertical bone augmentation (VBA), that is applied in conjunction with a barrier system. This study was performed to determine whether volume control of a three-dimensional (3D) printed nylon cap in the rat calvarial partial thickness bone defect would induce qualitative and quantitative differences in vertical bone regeneration.
A rat calvarial partial thickness bone defect was prepared and the 3D cap covered the defect to induce VBA, while the control group was left without cap placement. After six weeks the animals were sacrificed, and the calvaria were prepared for micro-CT (μCT) and histology.
Quantitative μCT results showed that our cap system has significant osteoconductive properties, and the histology slide revealed new bone filled inside the cap.
The results clearly showed that this system was successful for VBA in a research animal model.
背景/目的：牙槽骨缺失通常通过牵张成骨或骨块移植来实现显著的垂直骨增量（VBA），并结合屏障系统应用。本研究旨在确定大鼠颅骨部分厚度骨缺损中三维（3D）打印尼龙帽的体积控制是否会在垂直骨再生方面引起定性和定量差异。
制备大鼠颅骨部分厚度骨缺损，用3D帽覆盖缺损以诱导VBA，而对照组不放置帽。六周后处死动物，制备颅骨用于微型计算机断层扫描（μCT）和组织学检查。
定量μCT结果表明，我们的帽系统具有显著的骨传导特性，组织学切片显示帽内充满新骨。
结果清楚地表明，该系统在研究动物模型中成功实现了VBA。
