Li Xiao-Yan, Shi Chen-Jie, Yu Deng-Guang, Liao Yao-Zu, Wang Xia
School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, China.
Biomed Mater Eng. 2014;24(6):2015-23. doi: 10.3233/BME-141011.
This study investigates quercetin-loaded zein nanoribbons, which were fabricated using different types of electrospinning processes. Using ethanol aqueous solutions as sheath fluids, the widths of quercetin-loaded zein nanoribbons (D, nm) could be manipulated simply through the adjustment of water contents(C) in the sheath fluids according to an equation of D=958-8.01C(r=0.9977), as indicated by the field emission scanning electron microscopic observations. X-ray diffraction and attenuated total reflectance Fourier transform infrared analysis suggested that the quercetin presented in the zein nanoribbons in an amorphous state due to their high compability resulted from hydrogen bonds. In vitro dissolution tests verified that nanoribbons from the coaxial process and single fluid process could provide drug sustained release profiles via a typical Fickian diffusion mechanism, and the former exhibited better performance than the later in terms of small initial burst effect and leveling-off release. Coaxial electrospinning with solvents can expand the capability of electrospinning in generating nanoproducts and provide a way for improving the nanoproducts' quality and functional performance.
本研究对采用不同类型静电纺丝工艺制备的载槲皮素玉米醇溶蛋白纳米带进行了研究。通过场发射扫描电子显微镜观察表明，以乙醇水溶液作为鞘液，载槲皮素玉米醇溶蛋白纳米带的宽度（D，纳米）可根据D = 958 - 8.01C（r = 0.9977）的公式，通过简单调整鞘液中的含水量（C）来进行控制。X射线衍射和衰减全反射傅里叶变换红外分析表明，由于氢键导致的高相容性，槲皮素以无定形状态存在于玉米醇溶蛋白纳米带中。体外溶出试验证实，同轴工艺和单流体工艺制备的纳米带可通过典型的菲克扩散机制实现药物缓释，并且前者在初始突释效应小和平稳释放方面表现优于后者。与溶剂的同轴静电纺丝可以扩展静电纺丝制备纳米产品的能力，并为提高纳米产品的质量和功能性能提供一种方法。
