Research Center for Analysis and Measurement, Donghua University, Shanghai 201620, China.
Colloids Surf B Biointerfaces. 2013 Feb 1;102:737-43. doi: 10.1016/j.colsurfb.2012.09.039. Epub 2012 Oct 2.
This study investigated drug/zein composite fibers prepared using a modified coaxial electrospinning process. With unspinnable acetic acid as sheath liquid and an electrospinnable co-dissolving solution of zein and ferulic acid (FA) as core fluid, the modified coaxial process could run smoothly and continuously without any clogging. Compared with those from the single-fluid electrospinning process, the FA-loaded zein fibers from the modified process were rounder and possessed higher quality in terms of diameter and distribution, as verified by scanning electron microscopic observations of their surface and cross-section. Differential scanning calorimetry and X-ray diffraction showed that fibers from both processes similarly formed a composite with the FA present in the zein matrix in an amorphous state. The driving force of encapsulation of FA into zein fibers was hydrogen bonding, as evidenced by the attenuated total reflectance Fourier transform infrared spectra. However, in vitro dissolution tests demonstrated that the fibers from the coaxial process exhibited better sustained-release profiles with a smaller initial burst effect and less tailing-off release compared with those from the single process. The modified coaxial electrospinning process is a useful tool for generating nanofibers with higher quality and improved functional performance.
本研究采用改进的同轴静电纺丝工艺制备了载药/玉米朊复合纤维。以不可纺的乙酸作为鞘液，以玉米朊和阿魏酸（FA）的共溶解溶液作为芯液，改进的同轴工艺可以平稳连续地运行，不会发生任何堵塞。与单流体静电纺丝工艺相比，从改进的工艺中得到的载有 FA 的玉米朊纤维更圆，在直径和分布方面质量更高，这可以通过对其表面和横截面的扫描电子显微镜观察得到验证。差示扫描量热法和 X 射线衍射表明，两种工艺得到的纤维均以无定形态将 FA 结合到玉米朊基质中。衰减全反射傅里叶变换红外光谱表明，FA 封装到玉米朊纤维中的驱动力是氢键。然而，体外溶解试验表明，与单工艺相比，同轴工艺制备的纤维具有更好的持续释放特性，初始突释效应较小，尾部释放较少。改进的同轴静电纺丝工艺是一种生成具有更高质量和改善功能性能的纳米纤维的有用工具。
