Sciascia S, Bertolaccini M L
Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, Division of Women's Health, King's College London, UK Centro di Ricerche di Immunologia Clinica ed Immunopatologia e Documentazione su Malattie Rare (CMID), Università di Torino, Italy.
Graham Hughes Lupus Research Laboratory, Lupus Research Unit, The Rayne Institute, Division of Women's Health, King's College London, UK
Lupus. 2014 Oct;23(12):1309-12. doi: 10.1177/0961203314538332.
Antibodies to prothrombin can be detected by ELISA using prothrombin coated onto irradiated plates (aPT) or the phosphatidylserine/prothrombin complex as antigen (aPS/PT) and they have been both related with the clinical manifestation of APS. Current evidence supports the concept that they belong to distinct populations of autoantibodies. Nevertheless, they can both be detected simultaneously in one patient. This mini-review will focus on data available on aPS/PT antibodies and their clinical utility in the diagnosis of APS.
使用包被在辐照板上的凝血酶原（活化部分凝血活酶时间，aPT）或磷脂酰丝氨酸/凝血酶原复合物作为抗原（抗磷脂酰丝氨酸/凝血酶原抗体，aPS/PT），通过酶联免疫吸附测定（ELISA）可检测到抗凝血酶原抗体，它们均与抗磷脂综合征（APS）的临床表现相关。目前的证据支持它们属于不同自身抗体群体的概念。然而，在一名患者中可同时检测到这两种抗体。本综述将聚焦于抗磷脂酰丝氨酸/凝血酶原抗体的现有数据及其在抗磷脂综合征诊断中的临床应用。
