State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Chin Med. 2014 Sep 11;9:21. doi: 10.1186/1749-8546-9-21. eCollection 2014.
Chaihu, prepared from the dried roots of Bupleurum Chinense DC (also known as bei Chaihu in Chinese) or Bupleurum scorzoneraefolium WILD (also known as nan Chaihu in Chinese), is a herbal medicine for harmonizing and soothing gan (liver) qi stagnation. Substantial pharmacological studies have been conducted on Chaihu and its active components (saikosaponins). One of the active components of Chaihu, saikosaponin-d, exhibited anticancer effects via autophagy induction. This article reviews the pharmacological findings for the roles of autophagy in the pharmacological actions of Chaihu and saikosaponins.
柴胡，由干燥的北柴胡（也被称为柴胡）或狭叶柴胡（也被称为南柴胡）的根制成，是一种调和肝气郁结的草药。对柴胡及其活性成分（柴胡皂苷）进行了大量的药理学研究。柴胡的一种活性成分柴胡皂苷-d 通过诱导自噬发挥抗癌作用。本文综述了自噬在柴胡及其柴胡皂苷的药理作用中的作用的药理学发现。
