用于评估慢性胰腺炎所致胰腺功能不全的总胆固醇水平。

Total cholesterol level for assessing pancreatic insufficiency due to chronic pancreatitis.

作者信息

Hirano Kenji, Saito Tomotaka, Mizuno Suguru, Tada Minoru, Sasahira Naoki, Isayama Hiroyuki, Matsukawa Miho, Umefune Gyotane, Akiyama Dai, Saito Kei, Kawahata Shuhei, Takahara Naminatsu, Uchino Rie, Hamada Tsuyoshi, Miyabayashi Koji, Mohri Dai, Sasaki Takashi, Kogure Hirofumi, Yamamoto Natsuyo, Nakai Yosuke, Koike Kazuhiko

机构信息

Department of Gastroenterology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

出版信息

Gut Liver. 2014 Sep;8(5):563-8. doi: 10.5009/gnl13366. Epub 2014 Apr 23.

DOI:10.5009/gnl13366

PMID:25228979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4164258/

Abstract

BACKGROUND/AIMS: To determine the nutritional markers important for assessing the degree of pancreatic insufficiency due to chronic pancreatitis in routine clinical practice.

METHODS

A total of 137 patients with chronic pancreatitis were followed up for more than 1 year. They were divided into two groups: a pancreatic diabetes mellitus (DM) group, consisting of 47 patients undergoing medical treatment for DM of pancreatic origin, and a nonpancreatic DM group, consisting of 90 other patients (including 86 patients without DM). Serum albumin, prealbumin, total cholesterol, cholinesterase, magnesium, and hemoglobin were compared between the two groups.

RESULTS

The total cholesterol was significantly lower in the pancreatic than the nonpancreatic DM group (164 mg/dL vs 183 mg/dL, respectively; p=0.0028). Cholinesterase was significantly lower in the former group (263 U/L vs 291 U/L, respectively; p=0.016). Among the 37 patients with nonalcoholic pancreatitis, there was no difference in the cholinesterase levels between the pancreatic and nonpancreatic (296 U/L vs 304 U/L, respectively; p=0.752) DM groups, although cholesterol levels remained lower in the former (165 mg/dL vs 187 mg/dL, respectively; p=0.052).

CONCLUSIONS

Cholinesterase levels are possibly affected by concomitant alcoholic liver injury. The total cholesterol level should be considered when assessing pancreatic insufficiency due to chronic pancreatitis.

摘要

背景/目的：确定在常规临床实践中对于评估慢性胰腺炎所致胰腺功能不全程度重要的营养指标。

方法

对137例慢性胰腺炎患者进行了超过1年的随访。他们被分为两组：胰腺性糖尿病（DM）组，由47例接受胰腺源性糖尿病治疗的患者组成；非胰腺性DM组，由其他90例患者（包括86例无糖尿病患者）组成。比较了两组患者的血清白蛋白、前白蛋白、总胆固醇、胆碱酯酶、镁和血红蛋白水平。

结果

胰腺性DM组的总胆固醇显著低于非胰腺性DM组（分别为164mg/dL和183mg/dL；p = 0.0028）。前一组的胆碱酯酶显著更低（分别为263U/L和291U/L；p = 0.016）。在37例非酒精性胰腺炎患者中，胰腺性和非胰腺性DM组之间的胆碱酯酶水平无差异（分别为296U/L和304U/L；p = 0.752），尽管前一组的胆固醇水平仍较低（分别为165mg/dL和187mg/dL；p = 0.052）。