非酒精性脂肪性肝病：对日益流行疾病的全面综述
Nonalcoholic fatty liver disease: a comprehensive review of a growing epidemic.
作者信息
Hassan Kareem, Bhalla Varun, El Regal Mohammed Ezz, A-Kader H Hesham
机构信息
Kareem Hassan, Varun Bhalla, Mohammed Ezz El Regal, H Hesham A-Kader, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The University of Arizona, Tucson, AZ 85724, United States.
出版信息
World J Gastroenterol. 2014 Sep 14;20(34):12082-101. doi: 10.3748/wjg.v20.i34.12082.
Abstract
Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity epidemic and the subsequent metabolic derangements brought along with it. Current efforts to elucidate the mechanism and causes of the disease have answered some questions, but much remains unknown about NAFLD. The aim of this article is to discuss the current knowledge regarding the pathogenesis of the disease, as well as the current and future diagnostic, preventative, and therapeutic options available to clinicians for the management of NAFLD.
摘要
非酒精性脂肪性肝病（NAFLD）正迅速成为全球范围内肝病最主要的病因之一。NAFLD发病率的上升与肥胖流行以及随之而来的代谢紊乱有关。目前为阐明该疾病的机制和病因所做的努力已经回答了一些问题，但关于NAFLD仍有许多未知之处。本文旨在讨论关于该疾病发病机制的现有知识，以及临床医生目前和未来可用于管理NAFLD的诊断、预防和治疗选择。
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