Dion Joanna M, McKee Chris, Tobias Joseph D, Sohner Paul, Herz Daniel, Teich Steven, Rice Julie, Barry N' Diris, Michalsky Marc
Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital and The Ohio State University 700 Children's Drive, Columbus 43205, Ohio, US.
Department of Urology , Nationwide Children's Hospital and The Ohio State University 700 Children's Drive, Columbus 43205, Ohio, US.
Int J Clin Exp Med. 2014 Aug 15;7(8):2242-7. eCollection 2014.
Managing ventilation and oxygenation during laparoscopic procedures in severely obese patients undergoing weight loss surgery presents many challenges. Pressure-controlled ventilation, volume-guaranteed (PCV-VG) is a dual-control mode of ventilation and an alternative to pressure (PC) or volume (VC) controlled ventilation. PCV-VG features a user-selected tidal volume target, that is auto-regulated and pressure controlled. We hypothesized that PCV-VG ventilation would provide improved oxygenation and ventilation during laparoscopic bariatric surgery with a lower peak inflating pressure (PIP) than either PC or VC ventilation.
This was a prospective cross-over cohort trial (n = 20). In random sequence each patient received the three modes of ventilation for 20 minutes during the laparoscopic portion of the procedure. For all modes of ventilation the goal tidal volume was 6-8 mL/kg, and the respiratory rate was adjusted to achieve normocarbia. The PIP, exhaled tidal volume, respiratory rate, and oxygen saturation were recorded every five minutes. At the end of 20 minutes, an arterial blood gas was obtained. Data were analyzed using a paired t-test.
PCV-VG and PC ventilation both resulted in significantly lower PIP (cmH2O) than VC ventilation (30.5 ± 3.0, 31.6 ± 4.9, and 36.3 ± 3.4 mmHg respectively; p < 0.01 for PCV-VG vs. VC and PC vs. VC). There was no difference in oxygenation (PaO2), ventilation (PaCO2) or hemodynamic variables between the three ventilation modes.
In adolescents and young adults undergoing laparoscopic bariatric surgery, PCV-VG and PC were superior to VC ventilation in their ability to provide ventilation with the lowest PIP.
在接受减肥手术的严重肥胖患者的腹腔镜手术过程中,管理通气和氧合存在诸多挑战。压力控制通气-容量保证(PCV-VG)是一种双重控制通气模式,是压力控制(PC)或容量控制(VC)通气的替代方法。PCV-VG具有用户选择的潮气量目标,该目标可自动调节并受压力控制。我们假设在腹腔镜减肥手术期间,PCV-VG通气比PC或VC通气能以更低的峰值充气压力(PIP)改善氧合和通气。
这是一项前瞻性交叉队列试验(n = 20)。在手术的腹腔镜部分,每位患者按随机顺序接受三种通气模式各20分钟。对于所有通气模式,目标潮气量为6-8 mL/kg,并调整呼吸频率以实现正常碳酸血症。每五分钟记录一次PIP、呼出潮气量、呼吸频率和氧饱和度。20分钟结束时,采集动脉血气。使用配对t检验分析数据。
PCV-VG和PC通气的PIP(cmH2O)均显著低于VC通气(分别为30.5±3.0、31.6±4.9和36.3±3.4 mmHg;PCV-VG与VC以及PC与VC相比,p < 0.01)。三种通气模式在氧合(PaO2)、通气(PaCO2)或血流动力学变量方面无差异。
在接受腹腔镜减肥手术的青少年和年轻人中,PCV-VG和PC在以最低PIP提供通气的能力方面优于VC通气。