新生儿和婴儿疫苗接种的非特异性效应：公共卫生、免疫学和概念性挑战。
Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges.
机构信息
Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau; OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Denmark; and Research Centre for Vitamins and Vaccines, Bandim Health Project, Statens Serum Institut, Copenhagen, Denmark.
Division of Infectious Disease, Department of Pediatrics, University of British Columbia, Child &Family Research Institute, Vancouver, Canada.
出版信息
Nat Immunol. 2014 Oct;15(10):895-9. doi: 10.1038/ni.2961.
Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to its greatest benefit. The World Health Organization has identified investigations into the molecular basis of nonspecific vaccine effects as a research priority.
疫苗可以通过调节对疫苗未专门针对的感染的反应产生非特异性效应。然而，由于缺乏对潜在免疫机制和分子因果关系的了解，无法充分利用这种潜在的强大的生命早期干预措施。世界卫生组织已将调查非特异性疫苗效应的分子基础确定为优先研究事项。
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