Van Scott E J, Yu R J
Department of Dermatology, Temple University School of Medicine, Philadelphia, Pennsylvania.
Cutis. 1989 Mar;43(3):222-8.
Alpha hydroxy acids and alpha keto acids applied topically in lower concentrations reduce the thickness of hyperkeratotic stratum corneum by reducing corneocyte cohesion at lower levels of the stratum corneum. This property permits efficient clinical control of dry skin, ichthyosis, follicular hyperkeratosis, and other conditions characterized by retention of stratum corneum. Applied topically in higher concentrations, these acids cause epidermolysis. This property provides a new alternative for treating seborrheic keratoses, keratoses commonly known as "age spots," actinic keratoses, and verrucae vulgares; all of which lesions involve distinct epidermal hyperplasia as well as retention of stratum corneum. Facial wrinkles can be modified with topical alpha hydroxy acids, applied in higher concentrations as office procedures, and concomitant daily home application of lower concentrations.
低浓度局部应用的α-羟基酸和α-酮酸可通过降低角质形成细胞在角质层较低水平的凝聚力来减少角化过度的角质层厚度。这一特性使得干性皮肤、鱼鳞病、毛囊角化过度以及其他以角质层潴留为特征的病症能够得到有效的临床控制。高浓度局部应用这些酸会导致表皮松解。这一特性为治疗脂溢性角化病、通常被称为“老年斑”的角化病、光化性角化病和寻常疣提供了一种新的选择；所有这些病变都涉及明显的表皮增生以及角质层潴留。面部皱纹可以通过高浓度局部应用α-羟基酸来改善，这作为门诊治疗手段，同时每日在家中应用低浓度产品。
