Lowe N J, Henderson T, Millikan L E, Smith S, Turk K, Parker F
Department of Dermatology, UCLA School of Medicine.
Cutis. 1989 Mar;43(3):283-6.
Nineteen patients with severe or recalcitrant rosacea were treated twice daily with 0.75 percent metronidazole topical gel in an open label study. Sixteen of the patients (84 percent) showed 50 percent or greater reduction in inflammatory lesions, while fifteen (79 percent) demonstrated a reduction in erythema severity and an improvement when evaluated by the investigator global assessment. No positive response was recorded for any patient prior to topical medication, whereas six of nine patients previously treated with tetracycline/minocycline demonstrated improvement. Seven of these nine patients responded to topical metronidazole treatment. One additional patient who did not respond to minocycline or desonide treatment showed a good response to topical metronidazole. Only one patient reported local irritation after using metronidazole. These results demonstrate that topical metronidazole gel is safe and effective for the treatment of severe or recalcitrant rosacea.
在一项开放标签研究中，19例重度或顽固性酒渣鼻患者每日两次外用0.75%甲硝唑凝胶进行治疗。16例患者（84%）的炎性皮损减少了50%或更多，而15例患者（79%）经研究者整体评估显示红斑严重程度减轻且病情改善。外用药物治疗前，所有患者均未出现阳性反应，而9例曾用四环素/米诺环素治疗的患者中有6例病情改善。这9例患者中有7例对外用甲硝唑治疗有反应。另外1例对米诺环素或地奈德治疗无反应的患者对外用甲硝唑治疗反应良好。仅1例患者在使用甲硝唑后报告有局部刺激。这些结果表明，外用甲硝唑凝胶治疗重度或顽固性酒渣鼻安全有效。
