亨廷顿舞蹈病中抗精神病药物所致肌张力障碍：一例报告

Neuroleptically induced dystonia in Huntington's disease: a case report.

作者信息

Schott K, Ried S, Stevens I, Dichgans J

机构信息

Neurologische Universitätsklinik, Tübingen, FRG.

出版信息

Eur Neurol. 1989;29(1):39-40. doi: 10.1159/000116375.

DOI:10.1159/000116375

PMID:2523309

Abstract

A patient with Huntington's disease developed acute dystonia whilst treated with tiapride. Sulpiride and tetrabenazine also induced dystonia. The anticholinergic biperiden depressed the syndrome but worsened psychopathology. Finally a combination of tetrabenazine and clozapine was successful in treatment of both chorea and dystonia. According to this observation, acute dystonia may occur in Huntington's disease as a consequence of neuroleptic treatment.

摘要

一名亨廷顿舞蹈症患者在接受硫必利治疗时出现急性肌张力障碍。舒必利和丁苯那嗪也诱发了肌张力障碍。抗胆碱能药物安坦减轻了该综合征，但加重了精神病理学症状。最后，丁苯那嗪和氯氮平联合使用成功治疗了舞蹈症和肌张力障碍。根据这一观察结果，在亨廷顿舞蹈症患者中，抗精神病药物治疗可能会导致急性肌张力障碍。