抗精神病药物治疗对亨廷顿舞蹈症患者不自主运动及运动表现的影响。
Effect of neuroleptic treatment on involuntary movements and motor performances in Huntington's disease.
作者信息
Girotti F, Carella F, Scigliano G, Grassi M P, Soliveri P, Giovannini P, Parati E, Caraceni T
出版信息
J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):848-52. doi: 10.1136/jnnp.47.8.848.
Abstract
Eighteen patients with Huntington's chorea were examined before and after neuroleptic treatment (haloperidol, pimozide, tiapride) to study the effect of such treatment on hyperkinesia and motor performance. Pimozide and haloperidol improved hyperkinesia; none of the drugs significantly affected motor performance. No correlation was found between the severity of hyperkinesia and motor performance scores, or between hyperkinesia and intelligence score, before and after therapy.
摘要
对18例亨廷顿舞蹈症患者在使用抗精神病药物（氟哌啶醇、匹莫齐特、硫必利）治疗前后进行检查，以研究此类治疗对运动亢进和运动表现的影响。匹莫齐特和氟哌啶醇改善了运动亢进；这些药物均未对运动表现产生显著影响。治疗前后，运动亢进的严重程度与运动表现评分之间，或运动亢进与智力评分之间均未发现相关性。
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