Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Province Key Laboratory of Industrial Biotechnology, Faculty of Materials Science & Engineering, Hubei University , Wuhan, China.
ACS Appl Mater Interfaces. 2014 Oct 22;6(20):17323-45. doi: 10.1021/am5045604. Epub 2014 Oct 3.
Because of the excellent mechanical properties and good biocompatibility, titanium-based metals are widely used in hard tissue repair, especially load-bearing orthopedic applications. However, bacterial infection and complication during and after surgery often causes failure of the metallic implants. To endow titanium-based implants with antibacterial properties, surface modification is one of the effective strategies. Possessing the unique organic structure composed of molecular and functional groups resembling those of natural organisms, functionalized polymeric nanoarchitectures enhance not only the antibacterial performance but also other biological functions that are difficult to accomplish on many conventional bioinert metallic implants. In this review, recent advance in functionalized polymeric nanoarchitectures and the associated antimicrobial mechanisms are reviewed.
由于钛基金属具有优异的机械性能和良好的生物相容性，因此被广泛应用于硬组织修复，特别是承重的骨科应用。然而，金属植入物在手术中和手术后的细菌感染和并发症常常导致其失效。为了赋予钛基植入物抗菌性能，表面改性是一种有效的策略。功能化聚合物纳米结构具有独特的有机结构，其分子和功能基团类似于天然生物，不仅增强了抗菌性能，还增强了许多传统生物惰性金属植入物难以实现的其他生物学功能。本综述主要讨论了功能化聚合物纳米结构的最新进展及其相关的抗菌机制。
