对II类磷酸肌醇3激酶细胞内作用的新见解。

New insight into the intracellular roles of class II phosphoinositide 3-kinases.

作者信息

Maffucci Tania, Falasca Marco

机构信息

*Inositide Signalling Group, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, U.K.

出版信息

Biochem Soc Trans. 2014 Oct;42(5):1378-82. doi: 10.1042/BST20140140.

DOI:10.1042/BST20140140

PMID:25233418

Abstract

In the last few years, an increased attention to class II isoforms of phosphoinositide 3-kinase (PI3K) has emerged, mainly fuelled by evidence suggesting a distinct non-redundant role for these enzymes compared with other PI3Ks. Despite this renewed interest, many questions remain on the specific functions regulated by these isoforms and their mechanism of activation and action. In the present review, we discuss results from recent studies that have provided some answers to these questions.

摘要

在过去几年中，对磷酸肌醇3激酶（PI3K）的II类亚型的关注日益增加，这主要是由一些证据所推动的，这些证据表明与其他PI3K相比，这些酶具有独特的非冗余作用。尽管人们重新产生了兴趣，但关于这些亚型所调节的具体功能及其激活和作用机制仍有许多问题。在本综述中，我们讨论了最近的研究所取得的结果，这些研究为这些问题提供了一些答案。