Truong Tuong L, Nga Vo T, Huy Duong T, Chi Huynh B L, Phung Nguyen K P
Nat Prod Commun. 2014 Aug;9(8):1179-80.
From Usnea aciculifera, a new depside aciculiferin A (1) was isolated, together with eleven known compounds, (+)-(12R)-usnic acid (2), methyl haematommate (3), methyl beta-orsellinate (4), methyl orsellinate (5), atranol (6), 7-hydroxy-5-methoxy-6-methylphthalide (7), norstictic acid (8), stictic acid (9), atranorin (10), barbatinic acid (11) and diffractaic acid (12). Their chemical structures were elucidated by 1D and 2D NMR spectroscopic as well as HR-ESI-MS analysis. Usnic acid (2) and depside diffractaic acid (12) presented in high yield of around 1.5% of the dried material. Some lichen substances inhibited the growth of some cancer cell lines. Three depsides, 1, 11 and 12, were evaluated for their cytotoxic activity against HeLa (human epithelial carcinoma), NCI-H460 (human lung cancer) and MCF-7 (human breast cancer) cell lines at the concentration of 100 microg/mL. Depside 1 showed good and depside 12 strong cytotoxic activity against three surveyed cancer cell lines.
从针叶松萝中分离出一种新的缩酚酸针叶松萝酸A（1），以及十一种已知化合物，（+）-（12R）-松萝酸（2）、血盘菌酸甲酯（3）、β-苔色酸甲酯（4）、苔色酸甲酯（5）、阿特拉诺林（6）、7-羟基-5-甲氧基-6-甲基苯酞（7）、降斑点酸（8）、斑点酸（9）、黑茶渍素（10）、巴巴亭酸（11）和衍射酸（12）。通过一维和二维核磁共振光谱以及高分辨电喷雾电离质谱分析确定了它们的化学结构。松萝酸（2）和缩酚酸衍射酸（12）的产量较高，约占干燥材料的1.5%。一些地衣物质抑制某些癌细胞系的生长。对三种缩酚酸1、11和12在100μg/mL浓度下对HeLa（人上皮癌）、NCI-H460（人肺癌）和MCF-7（人乳腺癌）细胞系的细胞毒性活性进行了评估。缩酚酸1对三种受试癌细胞系表现出良好的细胞毒性活性，缩酚酸12表现出较强的细胞毒性活性。
