烧伤后内毒素血症：早期切除对循环内毒素水平的影响。

Endotoxemia after burn injury: effect of early excision on circulating endotoxin levels.

作者信息

Dobke M K, Simoni J, Ninnemann J L, Garrett J, Harnar T J

机构信息

Department of Surgery, University of California, San Diego, CA 92103.

出版信息

J Burn Care Rehabil. 1989 Mar-Apr;10(2):107-11. doi: 10.1097/00004630-198903000-00002.

DOI:10.1097/00004630-198903000-00002

PMID:2523397

Abstract

Serial circulating endotoxin measurements (quantitative chromogenic limulus assay) were performed in sera from 19 burned patients to determine the profile of circulating serial circulating endotoxin after burn and the effect of early wound excision on serial circulating endotoxin level. Results indicate an early endotoxemia with the peak serial circulating endotoxin levels 7 to 12 hours and 4 days after burn. More importantly, the level of circulating serial circulating endotoxin can be diminished by early excision; late wound excision was associated with a transient increase of serial circulating endotoxin level. Early excision, therefore, may play a critical role in limiting endotoxemia after burn injury.

摘要

对19例烧伤患者的血清进行了连续循环内毒素测量（定量显色鲎试剂法），以确定烧伤后循环内毒素的变化情况以及早期伤口切除对连续循环内毒素水平的影响。结果表明，烧伤后7至12小时和4天出现早期内毒素血症，且连续循环内毒素水平达到峰值。更重要的是，早期切除可降低循环内毒素水平；晚期伤口切除则与循环内毒素水平的短暂升高有关。因此，早期切除可能在限制烧伤后内毒素血症方面起关键作用。