Winchurch R A, Thupari J N, Munster A M
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Md.
Surgery. 1987 Nov;102(5):808-12.
With use of a quantitative limulus assay, the levels of circulating endotoxins were examined in a population of burn patients with injuries covering 1% to 88% of the total body surface area (TBSA). In cases in which the injury was less than 20% TBSA, the increases in endotoxins were only 35% as compared with those of normal controls. As the extent of injury increased, the levels of endotoxins also increased: burns between 21% and 40% TBSA showed average increases of over 350% and burns in excess of 40% showed increases of 500%. The relationship between burn size and total endotoxin burden was significant (p = less than 0.01). Time-course studies indicated that in most cases, peak endotoxin levels occurred 3 to 4 days after injury. The data also showed that there was no relationship between the age of the patient and the extent of the endotoxin increase.
使用定量鲎试剂检测法，对烧伤面积占全身表面积（TBSA）1%至88%的烧伤患者群体的循环内毒素水平进行了检测。在烧伤面积小于20%TBSA的病例中，内毒素增加量仅为正常对照组的35%。随着损伤程度的增加，内毒素水平也升高：烧伤面积在21%至40%TBSA之间的患者，内毒素平均增加超过350%，而烧伤面积超过40%的患者，内毒素增加500%。烧伤面积与总内毒素负荷之间的关系具有显著性（p＜0.01）。时间进程研究表明，在大多数情况下，内毒素水平峰值出现在受伤后3至4天。数据还显示，患者年龄与内毒素增加程度之间没有关系。
