Upreti R K, Das M, Shanker R
Immunotoxicology Section, Industrial Toxicology Research Centre, Lucknow, India.
Vet Hum Toxicol. 1989 Feb;31(1):16-20.
Young healthy albino male mice were subjected to repeated exposure to kerosene by wrapping each of their hind feet with a muslin cloth (1 x 10 cm) wetted with kerosene (0.1 ml). Exposure varied from 15 to 60 min/day for 7 consecutive days. Repeated exposure to kerosene produced histologic changes in the foot pad skin and popliteal lymph nodes of mice and systemic toxic manifestations such as variation in hematologic profile, significant decreases in relative weight of thymus, spleen and abdominal lymph nodes and altered histology. Three weeks of non-exposure rest indicated the reversible nature of kerosene-induced toxicity. Furthermore, observations made in 24 human subjects chronically exposed to kerosene in an automobile workshop revealed high incidence of oil acne and dermatitis of varying degrees. The study demonstrates a need for caution where ever prolonged dermal exposure to kerosene in occupational situations obtains.
将年轻健康的白化雄性小鼠的每只后足用一块浸有煤油（0.1毫升）的平纹细布（1×10厘米）包裹，使其反复接触煤油。连续7天，每天接触时间从15分钟到60分钟不等。反复接触煤油会使小鼠的脚垫皮肤和腘窝淋巴结出现组织学变化，并产生全身毒性表现，如血液学指标变化、胸腺、脾脏和腹部淋巴结相对重量显著降低以及组织学改变。三周不接触的休息表明煤油诱导的毒性具有可逆性。此外，对24名长期在汽车修理车间接触煤油的人类受试者的观察发现，油性痤疮和不同程度的皮炎发病率很高。该研究表明，在职业环境中，只要长时间皮肤接触煤油，就需要谨慎。
